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3.4.24.82: ADAMTS-4 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.82

Reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.82 ADAMTS-4 endopeptidase

Cloned

Cloned on EC 3.4.24.82 - ADAMTS-4 endopeptidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
ADAMTS-4 and ADAMTS-5
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expressed in 293-EBNA cells
expressed in Chinese hamster ovary/A2 cell line
-
expressed in CHO cells
-
expressed in Drosophila SF9 cells
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expressed in HEK-293 cells
expressed in HEK-293T cells
expressed in HEK293-EBNA cells
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expressed in Saccharomyces cerevisiae and COS-7 cells
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expressed in Saccharomyces cerevisiae strain AH109 and in Escherichia coli strain DH5alpha
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expressed in Sf9 cells
expression in neurons from cerebral cortex from rats
expression of ADAMTS-4 in CHO/A2 cells
expression of ADAMTS-4 in human chondrosarcoma JJ012 cells
expression of ADAMTS-5 in Drosophila S2 cells
expression of cDNA in COS-7 cells
expression of cDNA in Drosophila S2 cells
expression of full length aggrecanase-1 and a C-terminal truncated form lacking the disintegrin and TSP motif in Drosophila S2 cells
recombinantly expressed
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the full-length mature form of ADAMTS-4 with a C-terminally His-tagged sequence is expressed in an Epstein-Barr virus nuclear antigen-expressing human embryonic kidney 293 cell line, two C-terminal domain deletion enzymes containing both catalytic and disintegrin domains and the catalytic domain alone are expressed in Drosophila S2 cells
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