3.4.24.82: ADAMTS-4 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.

Reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.82 ADAMTS-4 endopeptidase

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Results	in table
48	Activating Compound
19	AA Sequence
17	Application
1	CAS Registry Number
28	Cloned(Commentary)
2	Crystallization (Commentary)
895	Disease/ Diagnostics
3	Expression
12	General Information
130	IC50 Value
215	Inhibitors
29	Ki Value [mM]
9	KM Value [mM]
5	Localization
4	Metals/Ions
22	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
105	Organism
15	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
6	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
96	Reference
101	Source Tissue
2	Specific Activity [micromol/min/mg]
127	Substrates and Products (Substrate)
7	Subunits
131	Synonyms
10	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.24.82 - ADAMTS-4 endopeptidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

molecular dynamics simulations and multiway explorative data analysis on ADAMTS4 complexed with Marimastat and two cis-1(S)2(R)-amino-2-indanol ligands, and comparison with proteases MMP13, ADAMTS5. Determinant characteristics for ligand binding and selectivity among the three enzymes are to be found in the different protein conformation flexibility

Homo sapiens

O75173

734700

vapour diffusion method with 10% PEG 4K, 0.1 M MES (pH 6.0)

Homo sapiens

-

682743