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3.4.24.82: ADAMTS-4 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.82

Reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =

Synonyms

a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.82 ADAMTS-4 endopeptidase

Source Tissue

Source Tissue on EC 3.4.24.82 - ADAMTS-4 endopeptidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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from patients with stable effort angina pectoris, acute coronary syndromes and in controls. Higher levels of ADAMTS4 are found with progression of coronary artery disease from stable effort angina pectoris to unstable angina pectoris to non-ST-segment elevation acute myocardial infarction and to ST-segment elevation acute myocardial infarction
Manually annotated by BRENDA team
mRNA is present in heart tissue
Manually annotated by BRENDA team
ADAMTS-4 mRNA is relatively abundant in tubulogenic and control HUVEC cultures. Both mRNA and protein are significantly elevated in tubulogenic cultures versus controls
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
ADAMTS-4 is the highest expressed aggrecanase in normal larynx, while ADAMTS-5 is the main aggrecanase in laryngeal squamous cell carcinoma
Manually annotated by BRENDA team
mRNA is present in lung tissue
Manually annotated by BRENDA team
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metastatic lymph node
Manually annotated by BRENDA team