3.4.24.82: ADAMTS-4 endopeptidase
This is an abbreviated version!
For detailed information about ADAMTS-4 endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.82
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3.4.24.82
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cartilage
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metalloproteinase
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thrombospondin
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disintegrin
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osteoarthritis
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chondrocytes
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collagen
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adamts-5
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articular
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joint
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proteoglycans
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degeneration
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disc
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mmp-1
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knee
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intervertebral
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interleukin-1
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explants
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tnf
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synovial
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versican
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timp-3
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degener
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pulposus
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glycosaminoglycans
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chondroitin
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adams
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aggrecanase-2
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neoepitope
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motifs-4
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arthritic
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disintegrin-like
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chondroprotective
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intra-articular
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aggrecanolysis
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meniscus
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brevican
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subchondral
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matrix-degrading
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interglobular
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col2a1
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thrombospondin-like
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aggrecanase-mediated
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cartilage-degrading
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fibromodulin
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fibrosus
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il-1-induced
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safranin
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medicine
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nitege
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degradation
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anti-catabolic
- 3.4.24.82
- cartilage
- metalloproteinase
- thrombospondin
-
disintegrin
- osteoarthritis
- chondrocytes
- collagen
- adamts-5
-
articular
- joint
- proteoglycans
- degeneration
- disc
- mmp-1
- knee
-
intervertebral
- interleukin-1
-
explants
- tnf
- synovial
- versican
- timp-3
-
degener
- pulposus
- glycosaminoglycans
- chondroitin
-
adams
- aggrecanase-2
-
neoepitope
-
motifs-4
-
arthritic
-
disintegrin-like
-
chondroprotective
-
intra-articular
-
aggrecanolysis
- meniscus
- brevican
-
subchondral
-
matrix-degrading
-
interglobular
-
col2a1
-
thrombospondin-like
-
aggrecanase-mediated
-
cartilage-degrading
- fibromodulin
-
fibrosus
-
il-1-induced
-
safranin
- medicine
-
nitege
- degradation
-
anti-catabolic
Reaction
Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-/-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan =
Synonyms
a disintegrin and metalloprotease with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and metalloproteinase with thrombospondin motifs 4, a disintegrin and metalloproteinase with thrombospondin motifs-4, a disintegrin and metalloproteinase with thrombospondin-1-like motifs, a disintegrin-like and metalloproteinase with thrombospondin motifs-4, a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4, ADAMTS 4, ADAMTS-1, ADAMTS-4, ADAMTS-4 [a disintegrin and metalloproteinase with thrombospondin motifs-4], ADAMTS-4-2, ADAMTS4, agg-1, aggrecanase, aggrecanase 1, aggrecanase-1, disintegrin and metalloproteinase with thrombospondin motif 4, TS-4
ECTree
3.4.24.82 ADAMTS-4 endopeptidaseAdvanced search results
results (
results (KI Value
KI Value on EC 3.4.24.82 - ADAMTS-4 endopeptidase
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.000065
(2R)-N4-hydroxy-2-(3-hydroxybenzyl)-N1-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide
or above, pH not specified in the publication, temperature not specified in the publication
0.000003
(2S,3R)-2-[(cyclopropylmethyl)amino]-N1-hydroxy-N4-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-methylbutanediamide
or above, pH not specified in the publication, temperature not specified in the publication
0.000079
marimastat
pH not specified in the publication, temperature not specified in the publication
additional information
additional information
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Ki(app) of N-terminal alanine-extension mutants and of position [-1] mutants of N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3
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0.00268
(E)-4-[2-(3,5-dihydroxyphenyl)ethenyl]1,2-benzenediol
-
pH 7.5, 37°C, substrate: C6-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-Gly-Thr-Lys(7-methoxycoumarin-4-yl)-Gly-GluLeuGluGly-ArgGly-Thr-Lys(Dnp)-Gly-Ile-Ser-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-NH2
0.00506
(E)-4-[2-(3,5-dihydroxyphenyl)ethenyl]1,2-benzenediol
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pH 7.5, 37°C, substrate: pH 7.5, 37°C, substrate: Lys(7-methoxycoumarin-4-yl)-Lys-Gln-Glu-Phe-Arg-Gly-Gln-Thr-Lys(Dnp)-NH2
0.0453
doxycycline
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rhADAMTS4(F213-R695), pH and temperature not specified in the publication
0.0611
doxycycline
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rhADAMTS4(F213-A579), pH and temperature not specified in the publication
0.0869
minocycline
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rhADAMTS4(F213-R695), pH and temperature not specified in the publication
0.0973
minocycline
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rhADAMTS4(F213-A579), pH and temperature not specified in the publication
0.0001
N-terminal domain of tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-3
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0.00013
N-terminal domain of tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-1
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0.00018
N-terminal domain of tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-2
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0.00064
N-terminal domain of tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-4
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0.00634
pyrogallol
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pH 7.5, 37°C, substrate: C6-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-Gly-Thr-Lys(7-methoxycoumarin-4-yl)-Gly-GluLeuGluGly-ArgGly-Thr-Lys(Dnp)-Gly-Ile-Ser-(Gly-Pro-Hyp-Pro-Hyp-Gly)2-Gly-Pro-Hyp-NH2
0.041
pyrogallol
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pH 7.5, 37°C, substrate: Lys(7-methoxycoumarin-4-yl)-Lys-Gln-Glu-Phe-Arg-Gly-Gln-Thr-Lys(Dnp)-NH2
0.12
tetracycline
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rhADAMTS4(F213-A579), pH and temperature not specified in the publication
0.761
tetracycline
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rhADAMTS4(F213-R695), pH and temperature not specified in the publication
0.00022
tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-1
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0.00022
tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-2
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0.0004
tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-3
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0.00051
tissue inhibitor of metalloproteinases-3
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pH 7.5, 37°C, isoenzyme ADAMTS4-4
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