3.4.24.63: meprin B

This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.

Word Map on EC 3.4.24.63

3.4.24.63

alzheimer

amyloid

abeta

gamma-secretase

beta-amyloid

plaque

amyloid-beta

beta-site

amyloidogenic

alpha-secretase

aspartyl

cerebral

presenilins

senile

neurodegenerative

bace-1

swedish

sappalpha

neuropathology

tau

neurotoxic

app-cleaving

neuroblastoma

beta-peptide

ectodomains

dementia

protein-cleaving

medicine

nicastrin

drug development

amyloidogenesis

tangles

isostere

memapsin

peptidomimetic

abeta1-40

appswe

ad-like

hydroxyethylene

neurofibrillary

adam10

beta-protein

ad-associated

endoproteolytic

insulin-degrading

non-amyloidogenic

betaapp

neprilysin

pharmacology

Reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =

Synonyms

beta-secretase, cell surface sheddase, h-meprin beta, MEP1B, mephrin beta, meprin A subunit beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, metalloprotease meprin beta, metalloproteinase meprin beta, Mmepb, More, mouse meprin beta, procollagen proteinase, Rmepb

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.63 meprin B

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Results	in table
15	Activating Compound
9	AA Sequence
4	Application
1	CAS Registry Number
28	Cloned(Commentary)
2	Crystallization (Commentary)
741	Disease/ Diagnostics
3	Expression
95	General Information
93	IC50 Value
157	Inhibitors
10	kcat/KM [mM/s]
29	Ki Value [mM]
27	KM Value [mM]
72	Localization
42	Metals/Ions
14	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
78	Organism
7	PDB ID
15	pH Optimum
1	pH Range
30	Posttranslational Modification
25	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
68	Reference
93	Source Tissue
4	Specific Activity [micromol/min/mg]
180	Substrates and Products (Substrate)
22	Subunits
78	Synonyms
20	Temperature Optimum [°C]
2	Temperature Stability [°C]
24	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.63 - meprin B

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133000

Homo sapiens

Q16820

recombinant deglycosylated enzyme, gel filtration

145000

148000

recombinant glycosylated enzyme, gel filtration

755294

154000

Rattus norvegicus

homooligomeric isoform, active, dimer, MALDI-TOF mass spectroscopy

652414

171000

Rattus norvegicus

homooligomeric isoform, latent, dimer, MALDI-TOF mass spectroscopy

652414

73000

Danio rerio

F1QRQ5, Q5RHM1, Q5RKM1

x * 73000, SDS-PAGE

683206

74000

Rattus norvegicus

x * 74000, deglycosylated enzyme, SDS-PAGE under reducing conditions

31380

76100

Rattus norvegicus

homooligomeric isoform, active, monomer, MALDI-TOF mass spectroscopy

652414

84000

Rattus norvegicus

x * 84000, expressed in human kidney 293 cells, deglycosylated form, SDS-PAGE under reducing conditions

31380

85500

Rattus norvegicus

homooligomeric isoform, latent, monomer, MALDI-TOF mass spectroscopy

652414

90000

Mus musculus

x * 90000, mouse, SDS-PAGE under reducing or non-reducing conditions

31024

97000

Rattus norvegicus

x * 97000, expressed in human kidney 293 cells, SDS-PAGE under reducing conditions

31380

additional information

2 entries