3.4.24.63: meprin B
This is an abbreviated version!
For detailed information about meprin B, go to the full flat file.
Word Map on EC 3.4.24.63
-
3.4.24.63
-
alzheimer
-
amyloid
-
abeta
-
gamma-secretase
-
beta-amyloid
-
plaque
-
amyloid-beta
-
beta-site
-
amyloidogenic
-
alpha-secretase
-
aspartyl
-
cerebral
-
presenilins
-
senile
-
neurodegenerative
-
bace-1
-
swedish
-
sappalpha
-
neuropathology
-
tau
-
neurotoxic
-
app-cleaving
-
neuroblastoma
-
beta-peptide
-
ectodomains
-
dementia
-
protein-cleaving
-
medicine
-
nicastrin
-
drug development
-
amyloidogenesis
-
tangles
-
isostere
-
memapsin
-
peptidomimetic
-
abeta1-40
-
appswe
-
ad-like
-
hydroxyethylene
-
neurofibrillary
-
adam10
-
beta-protein
-
ad-associated
-
endoproteolytic
-
insulin-degrading
-
non-amyloidogenic
-
betaapp
-
neprilysin
-
pharmacology
- 3.4.24.63
- alzheimer
-
amyloid
- abeta
- gamma-secretase
- beta-amyloid
- plaque
- amyloid-beta
-
beta-site
-
amyloidogenic
- alpha-secretase
-
aspartyl
- cerebral
-
presenilins
-
senile
- neurodegenerative
- bace-1
-
swedish
-
sappalpha
-
neuropathology
- tau
-
neurotoxic
-
app-cleaving
- neuroblastoma
- beta-peptide
- ectodomains
- dementia
-
protein-cleaving
- medicine
-
nicastrin
- drug development
-
amyloidogenesis
-
tangles
-
isostere
-
memapsin
-
peptidomimetic
- abeta1-40
-
appswe
-
ad-like
-
hydroxyethylene
-
neurofibrillary
- adam10
- beta-protein
-
ad-associated
-
endoproteolytic
-
insulin-degrading
-
non-amyloidogenic
-
betaapp
- neprilysin
- pharmacology
Reaction
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain =
Synonyms
beta-secretase, cell surface sheddase, h-meprin beta, MEP1B, mephrin beta, meprin A subunit beta, Meprin b, meprin B metalloprotease, meprin beta, meprin beta metalloproteinase, meprin metalloprotease, meprin metalloproteinase, meprin metalloproteinase beta, meprin-beta, meprinbeta, metalloprotease meprin, metalloprotease meprin B, metalloprotease meprin beta, metalloproteinase meprin beta, Mmepb, More, mouse meprin beta, procollagen proteinase, Rmepb
ECTree
3.4.24.63 meprin BAdvanced search results
results (
results (KI Value
KI Value on EC 3.4.24.63 - meprin B
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.000008
3-[(E)-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl]diazenyl]-7-nitronaphthalene-1,5-disulfonic acid
pH 7.5, 25°C
0.00003
3-[[(3-carboxyphenyl)sulfonyl-[2-(hydroxyamino)-2-oxo-ethyl]amino]methyl]benzoic acid
0.00003
3-[[[2-(hydroxyamino)-2-oxo-ethyl]-(4-methoxyphenyl)sulfonylamino]methyl]benzoic acid
0.014
DL-Pro-DL-Leu-Gly-NH2
pH and temperature not specified in the publication
0.0089
galardin
pH and temperature not specified in the publication
0.0074
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
pH and temperature not specified in the publication
0.0074
N4-hydroxy-N1-[3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
pH and temperature not specified in the publication
0.014
Pro-Leu-Gly-hydroxamate
pH and temperature not specified in the publication
0.00003
3-[[(3-carboxyphenyl)sulfonyl-[2-(hydroxyamino)-2-oxo-ethyl]amino]methyl]benzoic acid
pH 7.5, 30°C, recombinant enzyme
0.00003
3-[[(3-carboxyphenyl)sulfonyl-[2-(hydroxyamino)-2-oxo-ethyl]amino]methyl]benzoic acid
pH 7.4, 30°C, recombinant enzyme
0.00003
3-[[[2-(hydroxyamino)-2-oxo-ethyl]-(4-methoxyphenyl)sulfonylamino]methyl]benzoic acid
pH 7.5, 30°C, recombinant enzyme
0.00003
3-[[[2-(hydroxyamino)-2-oxo-ethyl]-(4-methoxyphenyl)sulfonylamino]methyl]benzoic acid
pH 7.4, 30°C, recombinant enzyme
0.002
actinonin
pH and temperature not specified in the publication
additional information
additional information
inhibition kinetics, overview
-
