3.4.23.B2: Simian immunodeficiency virus proteinase
This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.
Word Map on EC 3.4.23.B2
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3.4.23.B2
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transcriptase
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integrase
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retroviral
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foamy
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transframe
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mauritian
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dutpase
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pol-specific
- 3.4.23.B2
- transcriptase
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integrase
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retroviral
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foamy
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transframe
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mauritian
- dutpase
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pol-specific
Reaction
The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =
Synonyms
More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR
ECTree
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Substrates Products
Substrates Products on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase
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REACTION DIAGRAM
Ac-Ala-Thr-Leu-Asn-Phe-Pro-Ile-Ser-Pro-Ile-Glu-NH2 + H2O
Ac-Ala-Thr-Leu-Asn-Phe + Pro-Ile-Ser-Pro-Ile-Glu-NH2
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?
Ac-Arg-Ala-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 + H2O
Ac-Arg-Ala-Ser-Gln-Asn-Tyr-OH + Pro-Val-Val-NH2
Ac-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly-NH2 + H2O
Ac-Arg-Lys-Ile-Leu + Phe-Leu-Asp-Gly-NH2
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?
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 + H2O
Ac-Ser-Gln-Asn-Tyr + Pro-Val-Val-NH2
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?
acetyl-Arg-Ala-Ser-Gln-Asn-Tyr-Pro-Val-Val + H2O
acetyl-Arg-Ala-Ser-Gln-Asn-Tyr + Pro-Val-Val
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?
aminobenzoyl-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2 + H2O
?
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?
biotin-Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala-Pro-Gln-Phe-Ser-Leu-Trp-Arg-Arg + H2O
biotin-Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala + Pro-Gln-Phe-Ser-Leu-Trp-Arg-Arg
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?
Lys-Ala-Arg-Val-Nle-(NO2)Phe-Glu-Ala-Nle-Gly + H2O
Lys-Ala-Arg-Val-Nle + (NO2)Phe-Glu-Ala-Nle-Gly
oxidized insulin B chain + H2O
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cleavage sites: HLVE13-ALYL and EALY16-LVC[SO3-]G
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SIV Gag precursor protein + H2O
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determination of cleavage sites and substrate specificity
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troponin C + H2O
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cleavage sites: EEEL97-AECF and AEEL117-AEIF
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?
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val + H2O
Val-Ser-Gln-Asn-Tyr + Pro-Ile-Val
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additional information
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cleavage site in Lys-PE40, a construct based upon the Pseudomonas exotoxin OE66 that is missing domain I are: ANL-1-AEEA and GDAL389-LERN
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?
Ac-Arg-Ala-Ser-Gln-Asn-Tyr-OH + Pro-Val-Val-NH2
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?
Ac-Arg-Ala-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 + H2O
Ac-Arg-Ala-Ser-Gln-Asn-Tyr-OH + Pro-Val-Val-NH2
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?
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galactokinase engineered with individual cleavage sites. Cleaves the sites in the order of decreasing preference: Met-Met, Phe-Pro, Leu-Phe, Tyr-Pro, Phe-Leu, Leu-Ala
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?
galactokinase + H2O
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galactokinase engineered with individual cleavage sites. Cleaves the sites in the order of decreasing preference: Met-Met, Phe-Pro, Leu-Phe, Tyr-Pro, Phe-Leu, Leu-Ala
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?
Lys-Ala-Arg-Val-Nle + (NO2)Phe-Glu-Ala-Nle-Gly
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?
Lys-Ala-Arg-Val-Nle-(NO2)Phe-Glu-Ala-Nle-Gly + H2O
Lys-Ala-Arg-Val-Nle + (NO2)Phe-Glu-Ala-Nle-Gly
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?
Lys-Ala-Arg-Val-Nle-(NO2)Phe-Glu-Ala-Nle-Gly + H2O
Lys-Ala-Arg-Val-Nle + (NO2)Phe-Glu-Ala-Nle-Gly
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?
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lentiviral Gag polyprotein, proteolytic processing for activation, cleavage in the late stages of life cycle, required for maturation of the virion meaning a structural rearrangement required for infectivity in budding virions, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview
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Pr55Gag polyprotein + H2O
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lentiviral Gag polyprotein, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview
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Pr55Gag polyprotein + H2O
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PR cleaves Pr55Gag into its constituent domains: matrix (MA), capsid (CA), nucleocapsid (NC), and p6
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?