3.4.23.B2: Simian immunodeficiency virus proteinase

This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.

Reaction

The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =

Synonyms

More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B2 Simian immunodeficiency virus proteinase

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Results	in table
1	AA Sequence
1	Application
4	Cloned(Commentary)
8	Crystallization (Commentary)
3	General Stability
7	IC50 Value
35	Inhibitors
10	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
26	Organism
3	pH Optimum
2	pH Stability
5	pI Value
1	Posttranslational Modification
6	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
24	Reference
2	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
2	Storage Stability
21	Substrates and Products (Substrate)
5	Subunits
13	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0102

SFK 107457

Simian immunodeficiency virus

-

IC50: 0.0102 mM

647808

0.00013

SFK 108842

Simian immunodeficiency virus

-

IC50: 0.00013 mM

647808

0.000077

SFK 108922

Simian immunodeficiency virus

-

IC50: below 0.000077 mM

647808

0.02

SFK 109274

Simian immunodeficiency virus

-

IC50: above 0.02 mM

647808

0.0048

SFK 17461

Simian immunodeficiency virus

-

IC50: 0.0048 mM

647808

0.00063

SKF 108390

Simian immunodeficiency virus

-

IC50: 0.00063 mM

647808

0.008

SKF 108907

Simian immunodeficiency virus

-

IC50: 0.008 mM

647808