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3.4.23.B2: Simian immunodeficiency virus proteinase

This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.

Word Map on EC 3.4.23.B2

Reaction

The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =

Synonyms

More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B2 Simian immunodeficiency virus proteinase

KI Value

KI Value on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.023
1-naphthoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Val-Ile-2-pyridylmethylamine
-
pH 5.5, 30°C
0.2
Ac-cyclohexylacetyl-PSI[CH(OH)CH2]Val-Glu-Arg-NH2
-
pH 5.5, 30°C
0.000012
Ala-Ala-Phe-Psi[CH(OH)CH2]Gly-Val-ValOCH3
-
pH 4.7, 37°C
0.3
amastatin
-
pH 6, 37°C
0.3
chymostatin
-
pH 6, 37°C
0.006
H-Val-Ser-Gln-Asn-Leu-PSI[CH(OH)CH2]Val-Ile-Val-OH
-
pH 5.5, 30°C
0.003
pepstatin A
-
pH 6, 37°C
0.49
phenoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Phe-Ile-2-pyridylmethylamine
-
pH 5.5, 30°C
0.19
phenoxyacetyl-His-Leu-PSI[CH(OH)CH2]Phe-Ile-2-pyridylmethylamine
-
pH 5.5, 30°C
additional information
additional information
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