3.4.23.B2: Simian immunodeficiency virus proteinase

This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.

Reaction

The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =

Synonyms

More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B2 Simian immunodeficiency virus proteinase

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Results	in table
1	AA Sequence
1	Application
4	Cloned(Commentary)
8	Crystallization (Commentary)
3	General Stability
7	IC50 Value
35	Inhibitors
10	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
26	Organism
3	pH Optimum
2	pH Stability
5	pI Value
1	Posttranslational Modification
6	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
24	Reference
2	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
2	Storage Stability
21	Substrates and Products (Substrate)
5	Subunits
13	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

General Stability

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General Stability on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

8 M urea cause 50% quenching of the fluorescence emission

Simian immunodeficiency virus

-

647815

microcrystals are stable under mild acidic conditions

Simian immunodeficiency virus

-

647807

purified enzyme is unstable due to autopropteolysis

Simian immunodeficiency virus

-

647814