3.4.23.B2: Simian immunodeficiency virus proteinase

This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.

Reaction

The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =

Synonyms

More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B2 Simian immunodeficiency virus proteinase

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Results	in table
1	AA Sequence
1	Application
4	Cloned(Commentary)
8	Crystallization (Commentary)
3	General Stability
7	IC50 Value
35	Inhibitors
10	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
26	Organism
3	pH Optimum
2	pH Stability
5	pI Value
1	Posttranslational Modification
6	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
24	Reference
2	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
2	Storage Stability
21	Substrates and Products (Substrate)
5	Subunits
13	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

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Simian immunodeficiency virus

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647807

complex of the enzyme bound to the inhibitor SKF107457, hanging drop method of vapor diffusion

Simian immunodeficiency virus

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647816

crystal structure determination and analysis of free enzyme and enzyme-inhibitor complexes, e.g. with 1,2-epoxy-3-(4-nitrophenoxy)propane at 2.4 A resolution, or with SKF107457 at 2.5 A resolution

Simian immunodeficiency virus

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668793

enzyme covalently bound to the inhibitor 1,2-epoxy-3-(p-nitrophenoxy)propane. Crystals of the variant SIV PR S4H appear to have the same morphology as those obtained from wild-type enzyme

Simian immunodeficiency virus

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647818

hanging drop method

Simian immunodeficiency virus

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647804

hanging-drop crystallization of the K69H mutant enzyme with pepstatin A

Simian immunodeficiency virus

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647805

SIV protease product complex, hanging drop vapor diffusion method

Simian immunodeficiency virus

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647817

unliganded SIV protease crystals are grown by hanging drop vapor diffusion. Domain flexibility and structural implications for drug resistant mutations

Simian immunodeficiency virus

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647813