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Literature summary for 3.4.23.B2 extracted from

  • Tomasselli, A.G.; Bannow, C.A.; Deibel, M.R., Jr.; Hui, J.O.; Zurcher-Neely, H.A.; Reardon, I.M.; Smith, C.W.; Heinrikson, R.L.
    Chemical synthesis of a biotinylated derivative of the simian immunodeficiency virus protease. Purification by avidin affinity chromatography and autocatalytic activation (1992), J. Biol. Chem., 267, 10232-10237.
    View publication on PubMed
Search for more literature for 3.4.23.B2

Inhibitors

Inhibitors Comment Organism Structure
1-naphthoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Val-Ile-2-pyridylmethylamine
-
 Simian immunodeficiency virus
Ac-cyclohexylacetyl-PSI[CH(OH)CH2]Val-Glu-Arg-NH2
-
 Simian immunodeficiency virus
H-Val-Ser-Gln-Asn-Leu-PSI[CH(OH)CH2]Val-Ile-Val-OH
-
 Simian immunodeficiency virus
phenoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Phe-Ile-2-pyridylmethylamine
-
 Simian immunodeficiency virus
phenoxyacetyl-His-Leu-PSI[CH(OH)CH2]Phe-Ile-2-pyridylmethylamine
-
 Simian immunodeficiency virus

Organism

Organism UniProt Comment Textmining
Simian immunodeficiency virus
-
 chemically synthesized enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
 Simian immunodeficiency virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biotin-Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala-Pro-Gln-Phe-Ser-Leu-Trp-Arg-Arg + H2O
-
 Simian immunodeficiency virus biotin-Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala + Pro-Gln-Phe-Ser-Leu-Trp-Arg-Arg
-
 ?
additional information cleavage site in Lys-PE40, a construct based upon the Pseudomonas exotoxin OE66 that is missing domain I are: ANL-1-AEEA and GDAL389-LERN Simian immunodeficiency virus ?
-
 ?
oxidized insulin B chain + H2O cleavage sites: HLVE13-ALYL and EALY16-LVC[SO3-]G Simian immunodeficiency virus ?
-
 ?
troponin C + H2O cleavage sites: EEEL97-AECF and AEEL117-AEIF Simian immunodeficiency virus ?
-
 ?
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val + H2O
-
 Simian immunodeficiency virus Val-Ser-Gln-Asn-Tyr + Pro-Ile-Val
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006
-
 H-Val-Ser-Gln-Asn-Leu-PSI[CH(OH)CH2]Val-Ile-Val-OH pH 5.5, 30°C Simian immunodeficiency virus
0.023
-
 1-naphthoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Val-Ile-2-pyridylmethylamine pH 5.5, 30°C Simian immunodeficiency virus
0.19
-
 phenoxyacetyl-His-Leu-PSI[CH(OH)CH2]Phe-Ile-2-pyridylmethylamine pH 5.5, 30°C Simian immunodeficiency virus
0.2
-
 Ac-cyclohexylacetyl-PSI[CH(OH)CH2]Val-Glu-Arg-NH2 pH 5.5, 30°C Simian immunodeficiency virus
0.49
-
 phenoxyacetyl-His-cyclohexylacetyl-PSI[CH(OH)CH(OH)]Phe-Ile-2-pyridylmethylamine pH 5.5, 30°C Simian immunodeficiency virus