3.4.23.B2: Simian immunodeficiency virus proteinase
This is an abbreviated version!
For detailed information about Simian immunodeficiency virus proteinase, go to the full flat file.
Word Map on EC 3.4.23.B2
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3.4.23.B2
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transcriptase
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integrase
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retroviral
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foamy
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transframe
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mauritian
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dutpase
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pol-specific
- 3.4.23.B2
- transcriptase
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integrase
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retroviral
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foamy
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transframe
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mauritian
- dutpase
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pol-specific
Reaction
The enzyme may have a wide substrate specificity. Good cleavage of the peptide bonds Met-Met and Tyr-Pro. Cleavage is also observed at Phe-Pro, Phe-Leu, Leu-Phe, Leu-Ala, Glu-Ala and Tyr-Ala =
Synonyms
More, Pol polyprotein, retropepsin, Simian immunodeficiency virus protease, simian immunodeficiency virus retropepsin, SIV PR, SIV protease, SIV proteinase, SIV retropepsin, SIV-PR
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Natural Substrates Products on EC 3.4.23.B2 - Simian immunodeficiency virus proteinase
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REACTION DIAGRAM
Pr55Gag polyprotein + H2O
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lentiviral Gag polyprotein, proteolytic processing for activation, cleavage in the late stages of life cycle, required for maturation of the virion meaning a structural rearrangement required for infectivity in budding virions, cleavage in the phosphorylated capsid domains, the enzyme is not influenced by the preceeding phosphorylation, but cleaved sites are no longer phosphorylated, while incompletely cleaved capsid domains are phosphorylated to a greater extent, overview
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