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3.4.23.18: Aspergillopepsin I

This is an abbreviated version!
For detailed information about Aspergillopepsin I, go to the full flat file.

Word Map on EC 3.4.23.18

Reaction

hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk =

Synonyms

A. protease, Acid protease, ACP, AOAP, AP, APP, Asp f 13, Asp f 15, aspartic protease, aspartic protease P6281, Aspartic proteinase, aspergillopepsin, Aspergillopepsin A, Aspergillopepsin F, aspergillopepsin I, aspergillopepsin O, Aspergillopeptidase A, Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, Aspergillus niger acid proteinase, Aspergillus protease, Aspergillus saitoi acid proteinase, Avamorin, Awamorin, carboxyl protease, Carboxyl proteinase, carboxyl proteinase I, Denapsin, denapsin 2P, Denapsin XP 271, EC 3.4.23.6, extracellular aspartic protease, More, PepA, PEPO, Pepsin-type aspartic proteinase, proApp, Proctase, Proctase B, Proctase P, Proteinase B, Proteinase, Aspergillus acid, Proteinase, Aspergillus awamori acid, Proteinase, Aspergillus kawachii aspartic, Proteinase, Aspergillus saitoi acid, Sumizyme AP, Trypsinogen kinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.18 Aspergillopepsin I

Inhibitors

Inhibitors on EC 3.4.23.18 - Aspergillopepsin I

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-epoxy-3-(4-nitrophenoxy)propane
DAN
-
91.7% residual activity at 5 mM
Diazoacetyl-DL-norleucine methyl ester
dithiothreitol
-
90.1% residual activity at 5 mM
DL-1-Diazo-3-tosylamido-2-heptanone
-
in the presence of Cu2+
EDTA
-
87.3% residual activity at 5 mM
Fe3+
-
81.1% residual activity at 10 mM
Hg2+
-
74.8% residual activity at 10 mM
IAA
-
94.8% residual activity at 5 mM
K+
-
97.4% residual activity at 10 mM
L-1-Diazo-3-tosylamido-4-phenyl-2-butanone
-
in the presence of Cu2+
Mn2+
-
85.9% residual activity at 10 mM
N-Acetylimidazole
-
-
N-bromosuccinimide
N-ethylmaleimide
-
88.8% residual activity at 5 mM
Na+
-
92.54% residual activity at 10 mM
NaN3
-
78% residual activity at 5 mM
NBS
-
49.7% residual activity at 5 mM
pepstatin
pepstatin A
specific inhibition of the mature enzyme
phenylmethylsulfonyl fluoride
-
16.3% residual activity at 5 mM
polyoxyethylene lauryl ether
-
88.7% residual activity after 3 h at 1% (v/v)
-
sodium laurylbenzenesulfonic acid
-
5.5% residual activity after 3 h at 1% (v/v)
sodium perborate
-
92.1% residual activity after 3 h at 1% (v/v)
Streptomyces pepsin inhibitor
-
-
-
TLCK
-
93.3% residual activity at 5 mM
Urea
-
95.5% residual activity at 5 mM
Zn2+
-
89.1% residual activity at 10 mM
additional information
-