3.4.23.18: Aspergillopepsin I
This is an abbreviated version!
For detailed information about Aspergillopepsin I, go to the full flat file.
Word Map on EC 3.4.23.18
-
3.4.23.18
-
cathepsins
-
pepstatin
-
proteinases
-
lysosomal
-
hemoglobin
-
renin
-
candida
-
alzheimer
-
plasmodium
-
albicans
-
plasmepsins
-
beta-secretase
-
falciparum
-
zymogen
-
malaria
-
pepsinogen
-
amyloid
-
chymosin
-
subsite
-
carboxypeptidase
-
mucor
-
flap
-
polyproteins
-
procathepsin
-
scissile
-
peptidomimetic
-
pregnancy-associated
-
beta-amyloid
-
cheese
-
milk-clotting
-
gamma-secretase
-
aspartyl
-
d-like
-
antimalarial
-
rhizopus
-
beta-site
-
abeta
-
angiotensinogen
-
leupeptin
-
isostere
-
prosegment
-
nutrition
-
rhizomucor
-
cynara
-
microplus
-
miehei
-
autoprocessing
-
bace-1
-
parasitica
-
hookworm
-
boophilus
- 3.4.23.18
- cathepsins
- pepstatin
- proteinases
- lysosomal
- hemoglobin
- renin
- candida
- alzheimer
- plasmodium
- albicans
-
plasmepsins
- beta-secretase
- falciparum
- zymogen
- malaria
- pepsinogen
-
amyloid
- chymosin
-
subsite
- carboxypeptidase
- mucor
- flap
- polyproteins
-
procathepsin
-
scissile
-
peptidomimetic
-
pregnancy-associated
- beta-amyloid
-
cheese
-
milk-clotting
- gamma-secretase
-
aspartyl
- d-like
-
antimalarial
- rhizopus
-
beta-site
- abeta
- angiotensinogen
- leupeptin
-
isostere
- prosegment
- nutrition
- rhizomucor
- cynara
- microplus
- miehei
-
autoprocessing
- bace-1
- parasitica
- hookworm
- boophilus
Reaction
hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk =
Synonyms
A. protease, Acid protease, ACP, AOAP, AP, APP, Asp f 13, Asp f 15, aspartic protease, aspartic protease P6281, Aspartic proteinase, aspergillopepsin, Aspergillopepsin A, Aspergillopepsin F, aspergillopepsin I, aspergillopepsin O, Aspergillopeptidase A, Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, Aspergillus niger acid proteinase, Aspergillus protease, Aspergillus saitoi acid proteinase, Avamorin, Awamorin, carboxyl protease, Carboxyl proteinase, carboxyl proteinase I, Denapsin, denapsin 2P, Denapsin XP 271, EC 3.4.23.6, extracellular aspartic protease, More, PepA, PEPO, Pepsin-type aspartic proteinase, proApp, Proctase, Proctase B, Proctase P, Proteinase B, Proteinase, Aspergillus acid, Proteinase, Aspergillus awamori acid, Proteinase, Aspergillus kawachii aspartic, Proteinase, Aspergillus saitoi acid, Sumizyme AP, Trypsinogen kinase
ECTree
3.4.23.18 Aspergillopepsin IAdvanced search results
results (
results (Reference
top
Reference on EC 3.4.23.18 - Aspergillopepsin I
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lu, J.F.; Inoue, H.; Kimura, T.; Makabe, O.; Takahashi, K.
Molecular cloning of a cDNA for proctase B from Aspergillus niger var. macrosporus and sequence comparison with other aspergillopepsins I
Biosci. Biotechnol. Biochem.
59
954-955
1995
Aspergillus awamori, Aspergillus niger, Aspergillus phoenicis
Takeuchi, M.; Ueno, Y.; Ichishima, E.
Fluorogenic substrate of Aspergillus aspartic proteinase
Agric. Biol. Chem.
52
1279-1280
1988
Aspergillus phoenicis
-
Tello-Solis, S.R.; Hernandez-Arana, A.
Effect of irreversibility on the thermodynamic characterization of the thermal denaturation of Aspergillus saitoi acid proteinase
Biochem. J.
311
969-974
1995
Aspergillus phoenicis
Majima, E.; Oda, K.; Murao, S.; Ichishima, E.
Comparative study on the specificities of several fungal aspartic and acidic proteinases towards the tetradecapeptide of a renin substrate
Agric. Biol. Chem.
52
787-793
1988
Aspergillus oryzae, Aspergillus phoenicis, Aspergillus sojae
-
Yagi, F.; Fan, J.; Tadera, K.; Kobayashi, A.
Purification and characterization of carboxyl proteinase from Aspergillus kawachii
Agric. Biol. Chem.
50
1029-1033
1986
Aspergillus luchuensis
-
Bhumibhamon, O.
Precipitation and characteristics of acid protease of Aspergillus phoenicis produced with and without surfactant in the culture medium
Thai J. Agric. Sci.
15
157-172
1982
Aspergillus phoenicis
-
Panneerselvam, M.; Dhar, S.C.
Physico-chemical properties of the acid proteinase from A. fumigatus
Ital. J. Biochem.
30
63-74
1981
Aspergillus fumigatus
Bhumibhamon, O.
Some characreristics of the acid protease of Aspergillus awamori
Thai J. Agric. Sci.
12
27-33
1979
Aspergillus awamori
-
Ichishima, E.
Purification and mode of assay for acid proteinase of Aspergillus saitoi
Methods Enzymol.
19
397-406
1970
Aspergillus phoenicis, Aspergillus phoenicis R-3813
-
Kovaleva, G.G.; Shimanskaya, M.P.; Stepanov, V.M.
The site of diazoacetyl inhibitor attachment to acid proteinase of Aspergillus awamori--an analog of penicillopepsin and pepsin
Biochem. Biophys. Res. Commun.
49
1075-1081
1972
Aspergillus awamori
Morihara, K.; Oka, T.
Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability
Arch. Biochem. Biophys.
157
561-572
1973
Aspergillus niger, Aspergillus phoenicis, Aspergillus niger B
Davidson, R.; Gertler, A.; Hofmann, T.
Aspergillus oryzae acid proteinase. Purification and properties, and formation of pi-chymotrypsin
Biochem. J.
147
45-53
1975
Aspergillus oryzae
Takahashi, K.; Chang, W.J.
The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin
J. Biochem.
80
497-506
1976
Aspergillus niger, Aspergillus phoenicis
Tsujita, Y.; Endo, A.
Purification and characterization of the two molecular forms of Aspergillus oryzae acid protease
Biochim. Biophys. Acta
445
194-204
1976
Aspergillus oryzae
Tsujita, Y.; Endo, A.
Presence and partial characterization of internal acid protease of Aspergillus oryzae
Appl. Environ. Microbiol.
36
237-242
1978
Aspergillus oryzae, Aspergillus oryzae 365-U-64-1
Tanaka, N.; Takeuchi, M.; Ichishima, E.
Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity
Biochim. Biophys. Acta
485
406-416
1977
Aspergillus phoenicis
Chang, W.Y.; Horiuchi, S.; Takahashi, K.; Yamasaki, M.; Yamada, Y.
The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus
J. Biochem.
80
975-981
1976
Aspergillus niger
Iio, K.; Yamasaki, M.
Specificity of acid proteinase A from Aspergillus niger var. macrosporus towards B-chain of performic acid oxidized bovine insulin
Biochim. Biophys. Acta
429
912-924
1976
Aspergillus niger
Krishnan, S.; Vijayalakshmi, M.A.
Purification of an acid protease and a serine carboxypeptidase from Aspergillus niger using metal-chelate affinity chromatography
J. Chromatogr.
329
165-170
1985
Aspergillus niger
Tsujita, Y.; Endo, A.
Purification and characterization of the two molecular forms of membrane acid protease from Aspergillus oryzae
Eur. J. Biochem.
84
347-353
1978
Aspergillus oryzae
Cho, S.W.; Kim, N-j.; Choi, M.U.; Shin, W.
Structure of aspergillopepsin I from Aspergillus phoenicis: variations of the S1'-S2 subsite in aspartic proteinases
Acta Crystallogr. Sect. D
57
948-956
2001
Aspergillus phoenicis
Kamitori, S.; Ohtaki, A.; Ino, H.; Takeuchi, M.
Crystal structures of Aspergillus oryzae aspartic proteinase and its complex with an inhibitor pepstatin at 1.9A resolution
J. Mol. Biol.
326
1503-1511
2003
Aspergillus oryzae
Zhu, L.Y.; Nguyen, C.H.; Sato, T.; Takeuchi, M.
Analysis of secreted proteins during conidial germination of Aspergillus oryzae RIB40
Biosci. Biotechnol. Biochem.
68
2607-2612
2004
Aspergillus oryzae (Q06902), Aspergillus oryzae, Aspergillus oryzae RIB 40 (Q06902)
Ichishima, E.
Aspergillopepsin I
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
92-99
2004
Aspergillus awamori, Aspergillus foetidus, Aspergillus fumigatus, Aspergillus luchuensis, Aspergillus niger, Aspergillus oryzae, Aspergillus phoenicis, Aspergillus sojae, Aspergillus phoenicis R-3813
-
Landbo, A.K.; Pinelo, M.; Vikbjerg, A.F.; Let, M.B.; Meyer, A.S.
Protease-assisted clarification of black currant juice: synergy with other clarifying agents and effects on the phenol content
J. Agric. Food Chem.
54
6554-6563
2006
Aspergillus niger
Niyonzima, F.N.; More, S.S.
Purification and characterization of detergent-compatible protease from Aspergillus terreus gr
3 Biotech
5
61-70
2015
Aspergillus terreus, Aspergillus terreus gr.
Namvar, S.; Warn, P.; Farnell, E.; Bromley, M.; Fraczek, M.; Bowyer, P.; Herrick, S.
Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model
Clin. Exp. Allergy
45
982-993
2015
Aspergillus fumigatus (O60022), Aspergillus fumigatus A1160 (O60022)
-
Yu, X.; Ma, S.; Xu, Y.; Fu, C.; Jiang, C.; Zhou, C.
Construction and application of a novel genetically engineered Aspergillus oryzae for expressing proteases
Electron. J. Biotechnol.
29
32-38
2017
Aspergillus niger (A2R3L3)
-
Deng, J.; Huang, W.; Li, Z.; Lu, D.; Zhang, Y.; Luo, X.
Biocontrol activity of recombinant aspartic protease from Trichoderma harzianum against pathogenic fungi
Enzyme Microb. Technol.
112
35-42
2018
Trichoderma harzianum (Q334I5), Trichoderma harzianum, Trichoderma harzianum GIM 3.442 (Q334I5)
Takenaka, S.; Umeda, M.; Senba, H.; Koyama, D.; Tanaka, K.; Yoshida, K.; Doi, M.
Heterologous expression and characterisation of the Aspergillus aspartic protease involved in the hydrolysis and decolorisation of red-pigmented proteins
J. Sci. Food Agric.
97
95-101
2017
Aspergillus pseudoglaucus, Aspergillus pseudoglaucus MK82
Lim, C.; Lim, S.; Lee, B.; Cho, S.
Ginsenoside Rg1 exhibits anti-asthmatic activity in an Aspergillus protease-induced asthma model in mice
Nat. Prod. Commun.
13
415-418
2018
Aspergillus sp.
-
Yang, Y.; Iwamoto, A.; Kumrungsee, T.; Okazaki, Y.; Kuroda, M.; Yamaguchi, S.; Kato, N.
Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats
Nutr. Res.
44
60-66
2017
Aspergillus oryzae (Q06902), Aspergillus oryzae, Aspergillus oryzae RIB 40 (Q06902), Aspergillus oryzae ATCC 42149 (Q06902)
Yoshiya, T.; Yamashita, N.; Tsuda, S.; Oohigashi, K.; Masuda, S.; Kubodera, T.; Akashi, T.
HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease
Org. Biomol. Chem.
17
776-779
2019
Aspergillus oryzae
html completed
