3.4.23.18: Aspergillopepsin I

This is an abbreviated version!
For detailed information about Aspergillopepsin I, go to the full flat file.

Reaction

hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk =

Synonyms

A. protease, Acid protease, ACP, AOAP, AP, APP, Asp f 13, Asp f 15, aspartic protease, aspartic protease P6281, Aspartic proteinase, aspergillopepsin, Aspergillopepsin A, Aspergillopepsin F, aspergillopepsin I, aspergillopepsin O, Aspergillopeptidase A, Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, Aspergillus niger acid proteinase, Aspergillus protease, Aspergillus saitoi acid proteinase, Avamorin, Awamorin, carboxyl protease, Carboxyl proteinase, carboxyl proteinase I, Denapsin, denapsin 2P, Denapsin XP 271, EC 3.4.23.6, extracellular aspartic protease, More, PepA, PEPO, Pepsin-type aspartic proteinase, proApp, Proctase, Proctase B, Proctase P, Proteinase B, Proteinase, Aspergillus acid, Proteinase, Aspergillus awamori acid, Proteinase, Aspergillus kawachii aspartic, Proteinase, Aspergillus saitoi acid, Sumizyme AP, Trypsinogen kinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.18 Aspergillopepsin I

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Results	in table
12	Activating Compound
91	AA Sequence
6	Application
1	CAS Registry Number
9	Cloned(Commentary)
4	Crystallization (Commentary)
11	General Information
5	General Stability
55	Inhibitors
11	KM Value [mM]
36	Localization
12	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
64	Organism
1	Oxidation Stability
3	PDB ID
29	pH Optimum
7	pH Range
9	pH Stability
7	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
3	Reaction
1	Reaction Type
58	Reference
1	Renatured (Commentary)
41	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
113	Substrates and Products (Substrate)
27	Subunits
92	Synonyms
15	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
10	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.23.18 - Aspergillopepsin I

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

DNA and amino acid sequence determination and analysis, phylogenetic analysis of Aspergillus

2 entries

expressed in Escherichia coli Aspergillus oryzae strain 3.951

Aspergillus niger

A2R3L3

753407

expressed in Escherichia coli BL21(DE3) cells

Aspergillus pseudoglaucus

A0A146F0J0

755227

expressed in Pichia pastoris strain GS115

2 entries

gene apnS, DNA and amino acid sequence determination and analysis, phylogenetic analysis of Aspergillus, expression of the proenzyme in Saccharomyces cerevisiae, and in Escherichia coli inclusion bodies, expression of the N-terminal sequence in Escherichia coli

Aspergillus phoenicis

-

668812

gene pepA, located on chromosome 1, DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis of Aspergillus

Aspergillus niger

-

668812

proctase B, DNA and amino acid sequence determination and analysis, phylogenetic analysis of Aspergillus

Aspergillus oryzae

-

668812

DNA and amino acid sequence determination and analysis, phylogenetic analysis of Aspergillus

Aspergillus awamori

-

668812

DNA and amino acid sequence determination and analysis, phylogenetic analysis of Aspergillus

Aspergillus fumigatus

-

668812

expressed in Pichia pastoris strain GS115

Aspergillus pseudoglaucus

-

754494

expressed in Pichia pastoris strain GS115

Trichoderma harzianum

Q334I5

753450