3.4.23.18: Aspergillopepsin I

This is an abbreviated version!
For detailed information about Aspergillopepsin I, go to the full flat file.

Reaction

hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk =

Synonyms

A. protease, Acid protease, ACP, AOAP, AP, APP, Asp f 13, Asp f 15, aspartic protease, aspartic protease P6281, Aspartic proteinase, aspergillopepsin, Aspergillopepsin A, Aspergillopepsin F, aspergillopepsin I, aspergillopepsin O, Aspergillopeptidase A, Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, Aspergillus niger acid proteinase, Aspergillus protease, Aspergillus saitoi acid proteinase, Avamorin, Awamorin, carboxyl protease, Carboxyl proteinase, carboxyl proteinase I, Denapsin, denapsin 2P, Denapsin XP 271, EC 3.4.23.6, extracellular aspartic protease, More, PepA, PEPO, Pepsin-type aspartic proteinase, proApp, Proctase, Proctase B, Proctase P, Proteinase B, Proteinase, Aspergillus acid, Proteinase, Aspergillus awamori acid, Proteinase, Aspergillus kawachii aspartic, Proteinase, Aspergillus saitoi acid, Sumizyme AP, Trypsinogen kinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.18 Aspergillopepsin I

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Results	in table
12	Activating Compound
91	AA Sequence
6	Application
1	CAS Registry Number
9	Cloned(Commentary)
4	Crystallization (Commentary)
11	General Information
5	General Stability
55	Inhibitors
11	KM Value [mM]
36	Localization
12	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
64	Organism
1	Oxidation Stability
3	PDB ID
29	pH Optimum
7	pH Range
9	pH Stability
7	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
3	Reaction
1	Reaction Type
58	Reference
1	Renatured (Commentary)
41	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
113	Substrates and Products (Substrate)
27	Subunits
92	Synonyms
15	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Temperature Stability [°C]
10	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.23.18 - Aspergillopepsin I

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

Aspergillus oryzae

Aspergillus oryzae

-

30569

vapor diffusion method, crystallized in an orthorhombic system, space group P2(1)2(1)2(1), cell dimensions a : 49.4A, be : 79.4 A, c : 93.6 A, soaking method in complex with inhibitor pepstatin, crystals are transformed into a monoclinic system with space group C2 and cell dimensions of a : 106.8 A, be : 38.6 A, c : 78.7 A

Aspergillus oryzae

-

652904

crystal structure determination and analysis at 2.18 A resolution

Aspergillus phoenicis

-

668812

sitting-drop vapour diffusion, trapezoid shaped crystals, unit-cell parameters a : 82.19 A, b : 36.62 A, c : 104.94 A

Aspergillus phoenicis

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649170