3.4.22.49: separase
This is an abbreviated version!
For detailed information about separase, go to the full flat file.
Word Map on EC 3.4.22.49
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3.4.22.49
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chromatid
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sister
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anaphase
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cohesin
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mitosis
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securin
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spindle
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metaphase
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meiotic
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checkpoint
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centromeres
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kinetochore
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anaphase-promoting
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scc1
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prophase
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aneuploidy
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rec8
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cdc14
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rad21
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metaphase-to-anaphase
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centrosome
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shugoshins
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centriole
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sister-chromatid
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metaphase-anaphase
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disjunction
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medicaid
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disengagement
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prometaphase
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missegregation
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polo-like
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biorientation
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cyclosome
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kleisin
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meiosis-specific
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chiasmata
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pds1
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condensins
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medicine
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diagnostics
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nondisjunction
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molecular biology
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cdk1-dependent
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pp2acdc55
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kinetochore-microtubule
- 3.4.22.49
-
chromatid
-
sister
-
anaphase
- cohesin
-
mitosis
- securin
- spindle
-
metaphase
-
meiotic
-
checkpoint
-
centromeres
-
kinetochore
-
anaphase-promoting
- scc1
-
prophase
-
aneuploidy
- rec8
- cdc14
- rad21
-
metaphase-to-anaphase
- centrosome
- shugoshins
- centriole
-
sister-chromatid
-
metaphase-anaphase
-
disjunction
-
medicaid
-
disengagement
-
prometaphase
-
missegregation
-
polo-like
-
biorientation
-
cyclosome
-
kleisin
-
meiosis-specific
-
chiasmata
- pds1
-
condensins
- medicine
- diagnostics
-
nondisjunction
- molecular biology
-
cdk1-dependent
-
pp2acdc55
-
kinetochore-microtubule
Reaction
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage =
Synonyms
AESP, AtESP, Cut1, Cut1/separase, ESP, Esp1, ESPL1, sep-1, separase, separin, SSE, TbSep
ECTree
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Localization
Localization on EC 3.4.22.49 - separase
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additional information
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes
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in nondividing cells in healthy tissue, immunofluorescence microscopy
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separase is abundantly expressed within the cytoplasm of a broad range of human tumor cell lines, including MDA-MB-231 breast carcinoma cells
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes
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tumor cells significantly more abundant, immunofluorescence microscopy
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes
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while inhibiting separase, securin is able to promote nuclear accumulation of separase
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possibly localized in the nucleus, in the mitotic stage Cut1 is mobilized to the spindle poles and the spindle microtubules
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separase localizes to cortically located filamentous structures in prometaphase I upon oocyte maturation. After fertilization, separase disappears from these structures and appears on cortical granules by anaphase I
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additional information
Drosophila sp. (in: flies)
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separase binds terminin proteins and HP1, and that it is enriched at telomeres
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additional information
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human separase is associated with centrosomes but not with spindle before anaphase, featuring predominantly cytoplasmic localization in non-dividing cells
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additional information
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budding yeast Esp1 is localized to the centrosomes and spindle before anaphase
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additional information
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in fission yeast Cut1 features similar localization in the beginning of anaphase onset persisting on the spindle until mid-anaphase
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additional information
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Separase is present in the cell during the entire cell cycle, but excluded from the nucleus until the metaphase-anaphase transition
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