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Literature summary for 3.4.22.49 extracted from
- Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin (2000), Genes Cells, 5, 1-8.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | Cut1 seems to be localized in the cytoplasm | Schizosaccharomyces pombe | 5737 | - |
| nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
| nucleus | possibly localized in the nucleus, in the mitotic stage Cut1 is mobilized to the spindle poles and the spindle microtubules | Schizosaccharomyces pombe | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | Homo sapiens | - |
cleaved cohesin | - |
? |  |
| cohesin + H2O | Schizosaccharomyces pombe | - |
cleaved cohesin | - |
? | |
| cohesin + H2O | Saccharomyces cerevisiae | separase, i.e. Esp1, is implicated in the removal of cohesin which links sister chromatids in the S-phase and is postulated to be a specific protease or a positive regulator of protease against cohesin | cleaved cohesin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Schizosaccharomyces pombe |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | - |
Homo sapiens | fragments of cohesin | - |
? | |
| cohesin + H2O | - |
Schizosaccharomyces pombe | fragments of cohesin | - |
? | |
| cohesin + H2O | separase Esp1 is implicated in the removal of cohesin which links sister chromatids in the S-phase and is postulated to be a specific protease or a positive regulator of protease against cohesin | Saccharomyces cerevisiae | fragments of cohesin | - |
? | |
| cohesin + H2O | - |
Homo sapiens | cleaved cohesin | - |
? | |
| cohesin + H2O | - |
Schizosaccharomyces pombe | cleaved cohesin | - |
? | |
| cohesin + H2O | separase, i.e. Esp1, is implicated in the removal of cohesin which links sister chromatids in the S-phase and is postulated to be a specific protease or a positive regulator of protease against cohesin | Saccharomyces cerevisiae | cleaved cohesin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cut1 | - |
Schizosaccharomyces pombe |
| Esp1 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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