3.4.22.49: separase
This is an abbreviated version!
For detailed information about separase, go to the full flat file.
Word Map on EC 3.4.22.49
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3.4.22.49
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chromatid
-
sister
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anaphase
-
cohesin
-
mitosis
-
securin
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spindle
-
metaphase
-
meiotic
-
checkpoint
-
centromeres
-
kinetochore
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anaphase-promoting
-
scc1
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prophase
-
aneuploidy
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rec8
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cdc14
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rad21
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metaphase-to-anaphase
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centrosome
-
shugoshins
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centriole
-
sister-chromatid
-
metaphase-anaphase
-
disjunction
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medicaid
-
disengagement
-
prometaphase
-
missegregation
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polo-like
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biorientation
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cyclosome
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kleisin
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meiosis-specific
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chiasmata
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pds1
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condensins
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medicine
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diagnostics
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nondisjunction
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molecular biology
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cdk1-dependent
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pp2acdc55
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kinetochore-microtubule
- 3.4.22.49
-
chromatid
-
sister
-
anaphase
- cohesin
-
mitosis
- securin
- spindle
-
metaphase
-
meiotic
-
checkpoint
-
centromeres
-
kinetochore
-
anaphase-promoting
- scc1
-
prophase
-
aneuploidy
- rec8
- cdc14
- rad21
-
metaphase-to-anaphase
- centrosome
- shugoshins
- centriole
-
sister-chromatid
-
metaphase-anaphase
-
disjunction
-
medicaid
-
disengagement
-
prometaphase
-
missegregation
-
polo-like
-
biorientation
-
cyclosome
-
kleisin
-
meiosis-specific
-
chiasmata
- pds1
-
condensins
- medicine
- diagnostics
-
nondisjunction
- molecular biology
-
cdk1-dependent
-
pp2acdc55
-
kinetochore-microtubule
Reaction
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage =
Synonyms
AESP, AtESP, Cut1, Cut1/separase, ESP, Esp1, ESPL1, sep-1, separase, separin, SSE, TbSep
ECTree
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Metals Ions
Metals Ions on EC 3.4.22.49 - separase
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Ca2+
the enzyme contains a Ca2+-binding EF-hand motif, which can possibly affect separase interaction with the spindle, similar to the budding yeast Esp1, or alternatively Ca2+ might be a critical component for (auto-)catalysis
Ca2+
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Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif
Ca2+
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Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif
Ca2+
-
Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif