3.4.22.48: staphopain
This is an abbreviated version!
For detailed information about staphopain, go to the full flat file.
Word Map on EC 3.4.22.48
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3.4.22.48
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aureus
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staphylococcal
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streptococcal
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pyogenes
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staphostatins
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speb
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exotoxin
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pyrogenic
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aureolysin
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sspc
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gordonii
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pharmacology
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medicine
- 3.4.22.48
- aureus
-
staphylococcal
- streptococcal
- pyogenes
- staphostatins
- speb
-
exotoxin
-
pyrogenic
- aureolysin
- sspc
- gordonii
- pharmacology
- medicine
Reaction
broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate =
Synonyms
Ecp, extracellular cysteine protease, SCPA, Sscp A, Sscp B, SspB, SspB protein, staphopain, staphopain A, staphopain B, staphopain C, staphylopain
ECTree
3.4.22.48 staphopainAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.48 - staphopain
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
the enzyme cleaves collagen into peptide fragments that can support Staphylococcus aureus growth under nutrient-limited conditions
-
-
?
kininogen + H2O
kinin + ?
-
activation of human protein by SspA, kinin generation is responsible for infection associated pain and endema
-
-
?
CXCR2 + H2O
?
-
the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36
-
-
?
CXCR2 + H2O
?
-
the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36
-
-
?
cystatin C + H2O
?
specificity of staphopains when interacting with cystatins as natural protein substrates presented
-
-
?
cystatin C + H2O
?
specificity of staphopains when interacting with cystatins as natural protein substrates presented
-
-
?
cystatin D + H2O
?
specificity of staphopains when interacting with cystatins as natural protein substrates presented
-
-
?
cystatin D + H2O
?
specificity of staphopains when interacting with cystatins as natural protein substrates presented
-
-
?
Galectin-3 + H2O
?
the enzyme has galectin-3-processing capacity
-
-
?
Galectin-3 + H2O
?
the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection
-
-
?
Galectin-3 + H2O
?
the enzyme inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection
-
-
?
Galectin-3 + H2O
?
the enzyme has galectin-3-processing capacity
-
-
?
peptide + H2O
peptide proteolytically cleaved into fragments or single amino acids
-
-
-
-
?
peptide + H2O
peptide proteolytically cleaved into fragments or single amino acids
-
broad specificity
-
-
?
peptide + H2O
peptide proteolytically cleaved into fragments or single amino acids
-
-
-
-
?
protein + H2O
protein proteolytically cleaved into peptide fragments
-
-
-
-
?
protein + H2O
protein proteolytically cleaved into peptide fragments
-
broad specificity
-
-
?
protein + H2O
protein proteolytically cleaved into peptide fragments
-
enzyme may play a role in growth regulation
-
-
?
protein + H2O
protein proteolytically cleaved into peptide fragments
-
-
-
-
?
additional information
?
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staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus
-
-
?
additional information
?
-
-
staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus
-
-
?
additional information
?
-
-
staphopain A does not cleave human CXCR1
-
-
?
additional information
?
-
-
staphopain A does not cleave human CXCR1
-
-
?
additional information
?
-
staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus
-
-
?
