3.4.22.48: staphopain
This is an abbreviated version!
For detailed information about staphopain, go to the full flat file.
Word Map on EC 3.4.22.48
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3.4.22.48
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aureus
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staphylococcal
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streptococcal
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pyogenes
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staphostatins
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speb
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exotoxin
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pyrogenic
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aureolysin
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sspc
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gordonii
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pharmacology
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medicine
- 3.4.22.48
- aureus
-
staphylococcal
- streptococcal
- pyogenes
- staphostatins
- speb
-
exotoxin
-
pyrogenic
- aureolysin
- sspc
- gordonii
- pharmacology
- medicine
Reaction
broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate =
Synonyms
Ecp, extracellular cysteine protease, SCPA, Sscp A, Sscp B, SspB, SspB protein, staphopain, staphopain A, staphopain B, staphopain C, staphylopain
ECTree
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General Information
General Information on EC 3.4.22.48 - staphopain
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physiological function
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both staphopains (staphopain A and staphopain B) prolong the partial thromboplastin time of plasma in a dose- and activity-dependent manner, with SspB being 3fold more potent than ScpA. Staphopains also prolong the thrombin time of both plasma and fibrinogen, indicating that these enzymes can cause impaired plasma clotting through fibrinogen degradation
physiological function
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staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis
physiological function
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staphopains SspB and ScpA modulate Staphylococcus aureus biofilm integrity. ScpA enzyme has a conserved ability to inhibit biofilm formation
physiological function
SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production
physiological function
the enzyme cleaves collagen into peptide fragments that can support Staphylococcus aureus growth under nutrient-limited conditions
physiological function
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SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production
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physiological function
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staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis
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physiological function
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staphopains SspB and ScpA modulate Staphylococcus aureus biofilm integrity. ScpA enzyme has a conserved ability to inhibit biofilm formation
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