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Literature summary for 3.4.22.48 extracted from

  • Kulig, P.; Zabel, B.A.; Dubin, G.; Allen, S.J.; Ohyama, T.; Potempa, J.; Handel, T.M.; Butcher, E.C.; Cichy, J.
    Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin (2007), J. Immunol., 178, 3713-3720.
    View publication on PubMed
Search for more literature for 3.4.22.48

Application

Application Comment Organism
medicine studies on ability of staphopain B of Staphylococcus aureus to elicit and maintain a chronic inflammatory state, staphopain B suggested to mediate recruitment of specialized host cells, including immunoregulatory plasmacytoid dendritic cells and/or macrophages Staphylococcus aureus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular isolated from culture medium Staphylococcus aureus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus aureus staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus ?
-
 ?
additional information Staphylococcus aureus NCTC 8325 staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q2FZL3 strain 8325-4 including isogenic knockout mutants in the 8325-4 genetic background
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Staphylococcus aureus NCTC 8325 Q2FZL3 strain 8325-4 including isogenic knockout mutants in the 8325-4 genetic background
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Purification (Commentary)

Purification (Comment) Organism
recombinant and native protein, gel filtration Staphylococcus aureus

Source Tissue

Source Tissue Comment Organism Textmining
culture medium
-
 Staphylococcus aureus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 proteolytic cleavage of the C-terminus of chemerin, the tazarotene-induced gene 2 protein TIG2, by staphopain B determined by SDS-PAGE, HPLC-analysis and MALDI-TOF, cell-activating potential of chemerin cleavage products determined, clinical isolates of Staphylococcus aureus shown to activate chemerin, activation determined in the presence of plasma inhibitors, no activation of chemerin by staphopain B mutants observed Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus Staphylococcus aureus ?
-
 ?
additional information staphopain B shown as a potent trigger of chemerin, the tazarotene-induced gene 2 protein TIG2, normally acting as a ligand for the G-protein coupled receptor CMKLR1, activation shown by proteolytic cleavage of the C-terminus Staphylococcus aureus NCTC 8325 ?
-
 ?

Synonyms

Synonyms Comment Organism
SspB protein
-
 Staphylococcus aureus
staphopain B
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 Staphylococcus aureus