3.4.21.110: C5a peptidase
This is an abbreviated version!
For detailed information about C5a peptidase, go to the full flat file.
Word Map on EC 3.4.21.110
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3.4.21.110
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streptococci
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pyogenes
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serotype
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agalactiae
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pharyngitis
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medicine
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streptolysin
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streptokinase
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chemotaxins
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antiphagocytic
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dysgalactiae
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m-like
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lancefield
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impetigo
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equisimilis
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pyrogenic
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spycep
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laminin-binding
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fasciitis
- 3.4.21.110
- streptococci
- pyogenes
-
serotype
- agalactiae
- pharyngitis
- medicine
-
streptolysin
- streptokinase
-
chemotaxins
-
antiphagocytic
- dysgalactiae
-
m-like
-
lancefield
- impetigo
- equisimilis
-
pyrogenic
-
spycep
-
laminin-binding
- fasciitis
Reaction
the primary cleavage site is at His67-/-Lys68 in human C5a with a minor secondary cleavage site at Ala58-/-Ser59 =
Synonyms
C5a peptidase, GBS, GBS C5a peptidase, S08.020, SCFI, SCPA, ScpB, scpI, SCPZ, SEZ C5a peptidase, streptococcal chemotactic factor inactivator, surface-bound C5a peptidase
ECTree
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Substrates Products
Substrates Products on EC 3.4.21.110 - C5a peptidase
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REACTION DIAGRAM
Ac-SQLRANISH-4-nitroanilide + H2O
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weak chromogenic substrate
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Cys-Val-Val-Ala-Ser-Gln-Leu-Arg-Ala-Asn-Ile-His-Gln-Asp-Met-Gln-Leu-Gly-Arg
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substrate is cleaved into 2 fragments
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Cys-Val-Val-Ala-Ser-Gln-Leu-Arg-Ala-Asn-Ile-Ser-His-Lys-Asp-Met-Gln-Leu-Gly-Arg
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glutathione S-transferase-chemotaxin C5a-GFP + H2O
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fusion protein
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N-terminal His-tagged C5a fusion protein + H2O
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of cleaved HT-C5a indicate a loss of 830 Da, consistent with the removal of seven residues from the C-terminus
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chemotaxin C5a
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cleavage site is His-Lys rather than Lys-Asp, native protein is resistant to cleavage, suggesting that His-Lys bond is inaccessible prior to proteolytic cleavage by C5 convertase
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chemotaxin C5a + H2O
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cleaves between His67 and Lys68 or Ala58 and Ser59
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chemotaxin C5a + H2O
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removes a six-amino-acid fragment and thereby inactivates this chemotaxin
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chemotaxin C5a + H2O
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cleavage between histidine-67 and lysine-68 near the C-terminus
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no substrate: Cys-Val-Val-Ala-Ser-Gln-Leu-Arg-Ala-Asn-Ile-His-Pro-Lys-Asp-Met-Gln-Leu-Gly-Arg
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additional information
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alters the normal host inflammatory response by delaying the accumulation of PMNLs at the foci of streptococcal infection
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additional information
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binds directly to HEp2 and A549 cells, binds to the extracellular matrix protein fibronectin, role in cell invasion
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additional information
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mediates adherence to fibronectin, role in immune evasion by attenuating recruitment of polymorphonuclear leukocytes to the site of infection
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additional information
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no cleavage of rGST-enhanced green fluorescent protein
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additional information
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no cleavage of rGST-enhanced green fluorescent protein
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additional information
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native bovine serum albumin and other native proteins are highly resistant to proteolysis
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additional information
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fibronectin adhesin activity. Affinity for fibronectin is very high for both full-length recombinant ScpB and the 110-amino-acid phage display fragment
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additional information
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group B Streptococci do not bind to fibronectin in solution, but bind to fibronectin adsorbed onto a solid surface through ScpB, that binds to a motif created by the juxtaposition of multiple fibronectin molecules
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additional information
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fibronectin adhesin activity. Affinity for fibronectin is very high for both full-length recombinant ScpB and the 110-amino-acid phage display fragment
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