3.4.21.110: C5a peptidase

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For detailed information about C5a peptidase, go to the full flat file.

Reaction

the primary cleavage site is at His67-/-Lys68 in human C5a with a minor secondary cleavage site at Ala58-/-Ser59 =

Synonyms

C5a peptidase, GBS, GBS C5a peptidase, S08.020, SCFI, SCPA, ScpB, scpI, SCPZ, SEZ C5a peptidase, streptococcal chemotactic factor inactivator, surface-bound C5a peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.110 C5a peptidase

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Results	in table
1	Activating Compound
679	AA Sequence
18	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
5	General Information
13	Inhibitors
3	KM Value [mM]
2	Localization
1	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
30	Organism
5	PDB ID
4	pH Optimum
2	pH Range
1	Posttranslational Modification
18	Protein Variants
7	Purification (Commentary)
1	Reaction
12	Reaction Type
30	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
40	Substrates and Products (Substrate)
35	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.21.110 - C5a peptidase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100

Streptococcus pyogenes

-

30% activity after boiling for 10 min

651655

60

Streptococcus pyogenes

-

complete inactivation

651137

65

Streptococcus pyogenes

-

85% activity after 30 min, 75% activity after 60 min

651655