3.4.21.110: C5a peptidase
This is an abbreviated version!
For detailed information about C5a peptidase, go to the full flat file.
Word Map on EC 3.4.21.110
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3.4.21.110
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streptococci
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pyogenes
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serotype
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agalactiae
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pharyngitis
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medicine
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streptolysin
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streptokinase
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chemotaxins
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antiphagocytic
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dysgalactiae
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m-like
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lancefield
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impetigo
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equisimilis
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pyrogenic
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spycep
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laminin-binding
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fasciitis
- 3.4.21.110
- streptococci
- pyogenes
-
serotype
- agalactiae
- pharyngitis
- medicine
-
streptolysin
- streptokinase
-
chemotaxins
-
antiphagocytic
- dysgalactiae
-
m-like
-
lancefield
- impetigo
- equisimilis
-
pyrogenic
-
spycep
-
laminin-binding
- fasciitis
Reaction
the primary cleavage site is at His67-/-Lys68 in human C5a with a minor secondary cleavage site at Ala58-/-Ser59 =
Synonyms
C5a peptidase, GBS, GBS C5a peptidase, S08.020, SCFI, SCPA, ScpB, scpI, SCPZ, SEZ C5a peptidase, streptococcal chemotactic factor inactivator, surface-bound C5a peptidase
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Reference on EC 3.4.21.110 - C5a peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Anderson, E.T.; Wetherell, M.G.; Winter, L.A.; Olmsted, S.B.; Cleary, P.P.; Matsuka, Y.V.
Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes
Eur. J. Biochem.
269
4839-4851
2002
Streptococcus pyogenes
Cleary, P.P.; Prahbu, U.; Dale, J.B.; Wexler, D.E.; Handley, J.
Streptococcal C5a peptidase is a highly specific endopeptidase
Infect. Immun.
60
5219-5223
1992
Streptococcus pyogenes
Cheng, Q.; Stafslien, D.; Purushothaman, S.S.; Cleary, P.
The group B streptococcal C5a peptidase is both a specific protease and an invasin
Infect. Immun.
70
2408-2413
2002
Streptococcus pyogenes
Beckmann, C.; Waggoner, J.D.; Harris, T.O.; Tamura, G.S.; Rubens, C.E.
Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding
Infect. Immun.
70
2869-2876
2002
Streptococcus pyogenes
Stafslien, D.K.; Cleary, P.P.
Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate
J. Bacteriol.
182
3254-3258
2000
Streptococcus pyogenes
O'Connor, S.P.; Cleary, P.P.
In vivo Streptococcus pyogenes C5a peptidase activity: analysis using transposon- and nitrosoguanidine-induced mutants
J. Infect. Dis.
156
495-504
1987
Streptococcus pyogenes
Bohnsack, J.F.; Mollison, K.W.; Buko, A.M.; Ashworth, J.C.; Hill, H.R.
Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus
Biochem. J.
273
635-640
1991
Streptococcus sp.
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Purushothaman, S.S.; Park, H.; Cleary, P.P.
Promotion of fibronectin independent invasion by C5a peptidase into epithelial cells in group A Streptococcus
Indian J. Med. Res.
119
44-47
2004
Streptococcus sp.
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Shet, A.; Kaplan, E.; Johnson, D.; Cleary, P.P.
Human immunogenicity studies on group A streptococcal C5a peptidase (SCPA) as a potential vaccine against group A streptococcal infections
Indian J. Med. Res.
119 Suppl
95-98
2004
Streptococcus sp.
Park, H.S.; Cleary, P.P.
Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils
Infect. Immun.
73
7878-7886
2005
Streptococcus sp.
Terao, Y.; Yamaguchi, M.; Hamada, S.; Kawabata, S.
Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils
J. Biol. Chem.
281
14215-14223
2006
Streptococcus pyogenes, Streptococcus pyogenes SSI-9
Brown, C.K.; Gu, Z.Y.; Matsuka, Y.V.; Purushothaman, S.S.; Winter, L.A.; Cleary, P.P.; Olmsted, S.B.; Ohlendorf, D.H.; Earhart, C.A.
Structure of the streptococcal cell wall C5a peptidase
Proc. Natl. Acad. Sci. USA
102
18391-18396
2005
Streptococcus agalactiae
Wexler, D.E.; Chenoweth, D.E.; Cleary, P.P.
Mechanism of action of the group A streptococcal C5a inactivator
Proc. Natl. Acad. Sci. USA
82
8144-8148
1985
Streptococcus sp.
Cleary, P.P.; Matsuka, Y.V.; Huynh, T.; Lam, H.; Olmsted, S.B.
Immunization with C5a peptidase from either group A or B streptococci enhances clearance of group A streptococci from intranasally infected mice
Vaccine
22
4332-4341
2004
Streptococcus pyogenes
Hull, J.R.; Tamura, G.S.; Castner, D.G.
Interactions of the streptococcal C5a peptidase with human fibronectin
Acta Biomater.
4
504-513
2008
Streptococcus sp.
Santillan, D.A.; Andracki, M.E.; Hunter, S.K.
Protective immunization in mice against group B streptococci using encapsulated C5a peptidase
Am. J. Obstet. Gynecol.
198
114.e1-114.e6
2008
Streptococcus sp.
Tamura, G.S.; Hull, J.R.; Oberg, M.D.; Castner, D.G.
High-affinity interaction between fibronectin and the group B streptococcal C5a peptidase is unaffected by a naturally occurring four-amino-acid deletion that eliminates peptidase activity
Infect. Immun.
74
5739-5746
2006
Streptococcus sp., Streptococcus sp. COH1
Karmarkar, M.G.; Santosh, K.; Vineetha, V.; Mehta, P.R.; Kaplan, E.; Yurecho, R.; Cleary, P.P.
Human immune response to streptococcal C5a peptidase in Indian children and adults
Int. Congr. Ser.
1289
54-57
2006
Streptococcus sp.
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Kagawa, T.F.; OConnell, M.R.; Mouat, P.; Paoli, M.; OToole, P.W.; Cooney, J.C.
Model for substrate interactions in C5a peptidase from Streptococcus pyogenes: A 1.9 A crystal structure of the active form of ScpA
J. Mol. Biol.
386
754-772
2009
Streptococcus pyogenes
Locke, J.B.; Aziz, R.K.; Vicknair, M.R.; Nizet, V.; Buchanan, J.T.
Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development
PLoS ONE
3
e2824
2008
Streptococcus iniae
Gleich-Theurer, U.; Aymanns, S.; Haas, G.; Mauerer, S.; Vogt, J.; Spellerberg, B.
Human serum induces streptococcal c5a peptidase expression
Infect. Immun.
77
3817-3825
2009
Streptococcus agalactiae, Streptococcus pyogenes
Santillan, D.A.; Rai, K.K.; Santillan, M.K.; Krishnamachari, Y.; Salem, A.K.; Hunter, S.K.
Efficacy of polymeric encapsulated C5a peptidase-based group B streptococcus vaccines in a murine model
Am. J. Obstet. Gynecol.
205
249e1-249e8
2011
Streptococcus sp.
Yue, L.; Zhou, Y.; Zhang, S.
Epitope prediction, fractional expression and immunogenicity of streptococcal C5a peptidase from group B Streptococcus
Chin. J. Biol.
23
460-465
2010
Streptococcus sp.
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Wei, Z.; Fu, Q.; Chen, Y.; Li, M.; Cong, P.; Mo, D.; Liu, X.
Streptococcus equi ssp. zooepidemicus C5a peptidase, a putative invasin, induces protective immune response in mice
Res. Vet. Sci.
95
444-450
2013
Streptococcus equi subsp. zooepidemicus (B4U2T7), Streptococcus equi subsp. zooepidemicus MGCS10565 (B4U2T7)
Lynskey, N.N.; Reglinski, M.; Calay, D.; Siggins, M.K.; Mason, J.C.; Botto, M.; Sriskandan, S.
Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase
PLoS Pathog.
13
e1006493
2017
Streptococcus pyogenes serotype M1 (P58099)
Li, H.; Wang, S.; Zhao, Y.; Chen, Z.; Gu, G.; Guo, Z.
Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design
RSC Adv.
7
42056-42063
2017
Streptococcus pyogenes (B6ETQ5)
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