3.4.21.110: C5a peptidase
This is an abbreviated version!
For detailed information about C5a peptidase, go to the full flat file.
Word Map on EC 3.4.21.110
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3.4.21.110
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streptococci
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pyogenes
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serotype
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agalactiae
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pharyngitis
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medicine
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streptolysin
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streptokinase
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chemotaxins
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antiphagocytic
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dysgalactiae
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m-like
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lancefield
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impetigo
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equisimilis
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pyrogenic
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spycep
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laminin-binding
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fasciitis
- 3.4.21.110
- streptococci
- pyogenes
-
serotype
- agalactiae
- pharyngitis
- medicine
-
streptolysin
- streptokinase
-
chemotaxins
-
antiphagocytic
- dysgalactiae
-
m-like
-
lancefield
- impetigo
- equisimilis
-
pyrogenic
-
spycep
-
laminin-binding
- fasciitis
Reaction
the primary cleavage site is at His67-/-Lys68 in human C5a with a minor secondary cleavage site at Ala58-/-Ser59 =
Synonyms
C5a peptidase, GBS, GBS C5a peptidase, S08.020, SCFI, SCPA, ScpB, scpI, SCPZ, SEZ C5a peptidase, streptococcal chemotactic factor inactivator, surface-bound C5a peptidase
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.110 - C5a peptidase
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anti-SCPB antibody
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also provides protection against group A streptococcal infection
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anti-ScpA antibody
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blocks internalization of streptococci and neutralizes the C5a peptidase acitvity, enabling recruitment of polymorphoneutrophil leukocytes to sites of infection
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anti-ScpA antibody
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rise in convalescent anti-SCPA antibody in all children aged 2-12 years, mean convalescent anti-SCPA antibody level is twice the level of mean actue anti-SCPA antibody, which is statistically significant
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anti-ScpA antibody
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reduces group A streptococci colonization of nasal mucosa-associated lymphoid tissue administered alone or with cholera toxin
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additional information
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a high degree of group A streptococci colonization of nasal mucosa-associated lymphoid tissue in control mice immunized with phosphate-buffered saline only
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additional information
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anti-SCPA antibodies can neutralize the activity of the enzyme in vitro and in vivo
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