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BRENDA support

Literature summary for 3.4.21.110 extracted from

  • Karmarkar, M.G.; Santosh, K.; Vineetha, V.; Mehta, P.R.; Kaplan, E.; Yurecho, R.; Cleary, P.P.
    Human immune response to streptococcal C5a peptidase in Indian children and adults (2006), Int. Congr. Ser., 1289, 54-57.
No PubMed abstract available

Application

Application Comment Organism
medicine increased anti-SCPA IgG levels in rheumatic fever, rheumatic heart disease and acute glomerulo nephritis cases. The rise of anti-SCPA IgG observed in patients is irrespective of different emm types of group A streptococci strains isolated from these patients. Indian females show higher concentration of anti-SCPA antibodies than male patients. Anti-SCPA IgG1 and anti-SCPA IgG3 are the predominant subclasses of anti-SCPA antibody and clearly distinguish individuals with acute rheumatic fever from those free of streptococcal disease Streptococcus sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information anti-SCPA antibodies can neutralize the activity of the enzyme in vitro and in vivo Streptococcus sp.

Organism

Organism UniProt Comment Textmining
Streptococcus sp.
-
group A streptococci
-

Synonyms

Synonyms Comment Organism
SCPA
-
Streptococcus sp.