Purushothaman, S.S.; Park, H.; Cleary, P.P.
Promotion of fibronectin independent invasion by C5a peptidase into epithelial cells in group A Streptococcus (2004), Indian J. Med. Res., 119, 44-47.
No PubMed abstract available
Application
Application |
Comment |
Organism |
medicine |
acts as a potential invasin of group A streptococcus and promotes invasion independent of fibronectin |
Streptococcus sp. |
Protein Variants
Protein Variants |
Comment |
Organism |
additional information |
isogenic M1-mutant, expressses SCPA on cell surface |
Streptococcus sp. |
Inhibitors
Inhibitors |
Comment |
Organism |
Structure |
anti-ScpA antibody |
blocks internalization of streptococci and neutralizes the C5a peptidase acitvity, enabling recruitment of polymorphoneutrophil leukocytes to sites of infection |
Streptococcus sp. |
|
Localization
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
cell surface |
- |
Streptococcus sp. |
9986 |
- |
Organism
Organism |
UniProt |
Comment |
Textmining |
Streptococcus sp. |
- |
group A streptococcus strain 90 226 serotype M1 |
- |
Synonyms
Synonyms |
Comment |
Organism |
SCPA |
- |
Streptococcus sp. |