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Literature summary for 3.4.21.110 extracted from

  • Tamura, G.S.; Hull, J.R.; Oberg, M.D.; Castner, D.G.
    High-affinity interaction between fibronectin and the group B streptococcal C5a peptidase is unaffected by a naturally occurring four-amino-acid deletion that eliminates peptidase activity (2006), Infect. Immun., 74, 5739-5746.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.110

Application

Application Comment Organism
medicine fibronectin adhesin activity of scpB plays a role in virulence Streptococcus sp.

Cloned(Commentary)

Cloned (Comment) Organism
ScpB expressed as a fusion protein Streptococcus sp.

Protein Variants

Protein Variants Comment Organism
additional information mutant ScpBdelta, a common natural variant of ScpB, contains a 4-amino-acid deletion that eliminates peptidase activity. High affinity for fibronectin is maintained in ScpBdelta. ScpB and scpBdelta can complement the fibronectin-binding defect of the deletion mutant strain TOH97, that does not express scpB. Thus, the delta12 allele has no effect on the fibronectin binding of recombinant ScpB, recombinant ScpB-phage display fragment, or ScpB expressed by group B streptococci. High-affinity interaction between ScpB and immobilized fibronectin is responsible for the maintenance of the scpB gene in strains lacking C5a peptidase activity Streptococcus sp.

Organism

Organism UniProt Comment Textmining
Streptococcus sp.
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 group B streptococci
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Streptococcus sp. COH1
-
 group B streptococci
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus sp.

Source Tissue

Source Tissue Comment Organism Textmining

Storage Stability

Storage Stability Organism
-70°C Streptococcus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fibronectin adhesin activity. Affinity for fibronectin is very high for both full-length recombinant ScpB and the 110-amino-acid phage display fragment Streptococcus sp. ?
-
 ?
additional information fibronectin adhesin activity. Affinity for fibronectin is very high for both full-length recombinant ScpB and the 110-amino-acid phage display fragment Streptococcus sp. COH1 ?
-
 ?

Synonyms

Synonyms Comment Organism
ScpB
-
 Streptococcus sp.