3.4.19.9: folate gamma-glutamyl hydrolase
This is an abbreviated version!
For detailed information about folate gamma-glutamyl hydrolase, go to the full flat file.
Reaction
tetrahydropteroyl-(gamma-glutamyl)n +
(n-1) H2O
=
5,6,7,8-tetrahydrofolate +
(n-1) L-glutamate
Synonyms
At1g78680, AtGGH1, AtGGH2, carboxypeptidase G, conjugase, EC 3.4.12.10, EC 3.4.22.12, FGPH, folate conjugase, folate hydrolase, folic acid conjugase, folylpolyglutamate hydrolase, gamma-GH, gamma-Glu-X carboxypeptidase, gamma-glutamyl hydrolase, gamma-polyglutamic acid hydrolase, gammaGH, GGH, GGH2, hydrolase, gamma-glutamyl, LeGGH1, LeGGH2, LeGGH3, low gamma-glutamyl hydrolase, lysosomal gamma-glutamyl carboxypeptidase, PghP, poly(gamma-glutamic acid) endohydrolase, poly(glutamic acid) hydrolase II, polyglutamate hydrolase, pteroyl-poly-gamma-glutamate hydrolase, pteroylpoly-gamma-glutamyl hydrolase, zgammaGH
ECTree
Inhibitors
Inhibitors on EC 3.4.19.9 - folate gamma-glutamyl hydrolase
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6-diazo-5-oxo-norleucine
-
-
Ni2+
Micromonospora melanosporea
-
-
o-phenanthroline
Micromonospora melanosporea
-
-
p-Aminobenzoate
-
0.1 mM: no inhibition, 30% inhibition at 1.0 mM
p-aminobenzoylglutamate
-
slight
p-Hydroxymercuriphenylsulfonate
-
-
Phenylmethylsulfonylfluoride
poly-gamma-glutamic acid
-
-
pteroyldiglutamate
-
hydrolysis of pteroyltriglutamate
Pteroylheptaglutamate
-
hydrolysis of pteroyltriglutamate
pteroylpentaglutamate
-
hydrolysis of pteroyltriglutamate
Salicylazosulfapyridine
-
-
substituted and reduced pteroylglutamate
-
0.1 mM: not, 30% inhibition at 1.0 mM
4-hydroxymercuribenzoate
-
40% inhibition at 5 mM
4-hydroxymercuribenzoate
-
-
Cu2+
-
-
Cu2+
Micromonospora melanosporea
-
-
Dextran sulfate
-
-
-
EDTA
Micromonospora melanosporea
-
-
heparin
-
-
iodoacetate
-
-
iodoacetate
-
inhibition of wild-type enzyme and mutant enzymes C19A, C124A and C290A
p-hydroxymercuribenzoate
-
soluble intracellular enzyme is inhibited, membrane-bound brush-border enzyme not
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
PCMB
-
-
PCMB
Micromonospora melanosporea
-
-
Phenylmethylsulfonylfluoride
-
no inhibition
Phenylmethylsulfonylfluoride
-
-
Zn2+
-
0.1 mM zinc acetate, weak
Zn2+
-
bile enzyme inhibited at pH 7.5 but not at pH 4.5
additional information
-
no inhibition by EDTA, PMSF, or iodoacetic acid at 5 mM
-
additional information
-
the active centre is not blocked by thiol reagents or fluorophosphates
-
additional information
-
no inhibition by diphenylhydantoin or salicylazosulfapyridine; no inhibition by ethanol
-
additional information
-
no inhibition by alpha-diglutamic acid; no inhibition by alpha-triglutamic acid; no inhibition by glutamic acid
-
additional information
-
no inhibition by anionic polysaccharides; no inhibition by pteroic acid; no inhibition by pteroylglutamate
-
additional information
Micromonospora melanosporea
-
no inhibition by diisopropylfluorophosphate
-
additional information
-
no inhibition by competitive inhibitors of serine and cysteine proteinases; no inhibition by phosphoramidon
-
additional information
-
no inhibition by 2-mercaptomethylglutaric acid
-
additional information
-
no inhibition by anionic polysaccharides; no inhibition by pteroic acid; no inhibition by pteroylglutamate
-
3.4.19.9 folate gamma-glutamyl hydrolase
results (
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