3.4.19.9: folate gamma-glutamyl hydrolase

This is an abbreviated version!
For detailed information about folate gamma-glutamyl hydrolase, go to the full flat file.

Word Map on EC 3.4.19.9

3.4.19.9

polyglutamates

methotrexate

polyglutamylation

antifolate

casei

monoglutamates

pteroylpolyglutamate

sumo

monoglutamylated

5-methyltetrahydrofolate

deconjugation

trienzyme

pentaglutamate

rad6

diglutamate

punicic

medicine

analysis

Reaction

+ (n-1) H2O =

+ (n-1) L-glutamate

Synonyms

At1g78680, AtGGH1, AtGGH2, carboxypeptidase G, conjugase, EC 3.4.12.10, EC 3.4.22.12, FGPH, folate conjugase, folate hydrolase, folic acid conjugase, folylpolyglutamate hydrolase, gamma-GH, gamma-Glu-X carboxypeptidase, gamma-glutamyl hydrolase, gamma-polyglutamic acid hydrolase, gammaGH, GGH, GGH2, hydrolase, gamma-glutamyl, LeGGH1, LeGGH2, LeGGH3, low gamma-glutamyl hydrolase, lysosomal gamma-glutamyl carboxypeptidase, PghP, poly(gamma-glutamic acid) endohydrolase, poly(glutamic acid) hydrolase II, polyglutamate hydrolase, pteroyl-poly-gamma-glutamate hydrolase, pteroylpoly-gamma-glutamyl hydrolase, zgammaGH

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.19 Omega peptidases

3.4.19.9 folate gamma-glutamyl hydrolase

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Results	in table
10	Activating Compound
2840	AA Sequence
6	Application
1	CAS Registry Number
18	Cloned(Commentary)
3	Crystallization (Commentary)
184	Disease/ Diagnostics
1	Expression
3	General Information
5	General Stability
61	Inhibitors
33	KM Value [mM]
25	Localization
23	Metals/Ions
40	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
66	Organism
4	Pathway
30	PDB ID
29	pH Optimum
2	pH Range
3	pH Stability
8	Posttranslational Modification
26	Protein Variants
28	Purification (Commentary)
5	Reaction
1	Reaction Type
64	Reference
70	Source Tissue
14	Specific Activity [micromol/min/mg]
2	Storage Stability
152	Substrates and Products (Substrate)
20	Subunits
54	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
12	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.19.9 - folate gamma-glutamyl hydrolase

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0.057

5-formyltetrahydrofolate triglutamate

Danio rerio

Q6NY42

Vmax: 87.6 nmol/min/microg

692046

0.0076

5-L-glutamyl-4-nitroanilide

Geobacillus thermodenitrificans

pH 7.8, 52°C

702486

0.0012 - 0.00138

folic acid pentaglutamate

2 entries

0.0076

L-glutamic acid gamma-(4-nitroanilide)

Geobacillus thermodenitrificans

Vmax: 0.36 micromol/min/mg

702486

0.0214 - 0.049

methotrexate diglutamate

7 entries

0.00083

N5-methyltetrahydropteroyltetraglutamate

Gallus gallus

647290

0.00098 - 0.00186

p-aminobenzoylpentaglutamate

4 entries

0.0006

pteroyldiglutamate

Homo sapiens

647305

0.00021 - 0.0006

Pteroylheptaglutamate

2 entries

0.00052 - 0.00079

pteroylpentaglutamate

2 entries

pteroyltetraglutamate

Homo sapiens

647315

0.00055 - 0.0287

Pteroyltriglutamate

8 entries

additional information

2 entries