Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.19.9 extracted from

  • Horne, D.W.; Krumdieck, C.L.; Wagner, C.
    Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma (1981), J. Nutr., 111, 442-449.
    View publication on PubMed
Search for more literature for 3.4.19.9

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
p-Hydroxymercuriphenylsulfonate
-
 Rattus norvegicus
Zn2+ bile enzyme inhibited at pH 7.5 but not at pH 4.5 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pteroylpolyglutamate + H2O Rattus norvegicus possible contribution of biliary enzyme to intestinal absorption of folate polyglutamates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-diamino-10-methyl-pteroylglutamyl-gamma-glutamate + H2O
-
 Rattus norvegicus 2,4-diamino-10-methyl-pteroate + glutamate + gamma-glutamylglutamate bile enzyme at a ratio of 5:95 and plasma enzyme at a ratio of 23:77 ?
pteroylpolyglutamate + H2O possible contribution of biliary enzyme to intestinal absorption of folate polyglutamates Rattus norvegicus ?
-
 ?
pteroyltriglutamate + H2O
-
 Rattus norvegicus ?
-
 ?
pteroyltriglutamate + H2O
-
 Rattus norvegicus pteroylglutamate + glutamate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 5 and a second optimum at pH 6.7-7.5, bile Rattus norvegicus
6.2 7.5 plasma Rattus norvegicus
6.7 7.5 and a second optimum at pH 4.5-5.0, bile Rattus norvegicus