3.2.2.29: thymine-DNA glycosylase
This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.
Word Map on EC 3.2.2.29
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3.2.2.29
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demethylation
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5-methylcytosine
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cytosine
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deamination
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glycosylases
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5-carboxylcytosine
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mispairs
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5-formylcytosine
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5-hydroxymethylcytosine
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ten-eleven
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excises
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uracil-dna
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abasic
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methyl-cpg
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3,n4-ethenocytosine
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tdg-mediated
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5-hydroxymethyluracil
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sumo-1
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base-excision
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methyl-cpg-binding
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medicine
- 3.2.2.29
-
demethylation
- 5-methylcytosine
- cytosine
-
deamination
- glycosylases
- 5-carboxylcytosine
- mispairs
- 5-formylcytosine
-
5-hydroxymethylcytosine
-
ten-eleven
-
excises
-
uracil-dna
-
abasic
-
methyl-cpg
- 3,n4-ethenocytosine
-
tdg-mediated
- 5-hydroxymethyluracil
- sumo-1
-
base-excision
-
methyl-cpg-binding
- medicine
Reaction
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =
Synonyms
G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase
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Cloned
Cloned on EC 3.2.2.29 - thymine-DNA glycosylase
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DNA and amino acid sequence determination and analysis, phylogenetic tree of MUG proteins, expression in African green monkey kidney cells, the enzyme efficiently replaces the T with a C in G-T mismatched SV40 DNA exhibiting a G-T directed repair activity
expressed in Escherichia coli strain BL21 (DE3), MEF cells and HEK-293T cells
expression in Escherichia coli
gene Thd1, phylogenetic analysis, functional expression of a His-tagged truncated variant comprising residues 650M-1063N in Escherichia coli strain BL21 (DE3)
HeLa cell clones either stably transfected with a construct overexpressing human TDG from a cytomegalovirus promoter or with the corresponding vector only
phylogenetic analysis, expression of His-tagged TDG in Escherichia coli strain BL21 (DE3)