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3.2.2.29: thymine-DNA glycosylase

This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.

Word Map on EC 3.2.2.29

Reaction

Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =

Synonyms

G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.29 thymine-DNA glycosylase

Cloned

Cloned on EC 3.2.2.29 - thymine-DNA glycosylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, phylogenetic tree of MUG proteins, expression in African green monkey kidney cells, the enzyme efficiently replaces the T with a C in G-T mismatched SV40 DNA exhibiting a G-T directed repair activity
expressed in Escherichia coli
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3)-Gold cells
expressed in Escherichia coli Bl21-CodonPlus (DE3)-RP cells
-
expressed in Escherichia coli strain BL21 (DE3), MEF cells and HEK-293T cells
expressed in MEF cells
expression in Escherichia coli
expression in in cell-free extract and in Escherichia coli
expression in mismatch-transfected B16F10 cells
-
expression in NIH3T3 fibroblasts
-
expression of the His-tagged enzyme in Escherichia coli strain BL21 (DE3)
-
gene Thd1, phylogenetic analysis, functional expression of a His-tagged truncated variant comprising residues 650M-1063N in Escherichia coli strain BL21 (DE3)
HeLa cell clones either stably transfected with a construct overexpressing human TDG from a cytomegalovirus promoter or with the corresponding vector only
phylogenetic analysis, expression of His-tagged TDG in Escherichia coli strain BL21 (DE3)