3.2.2.29: thymine-DNA glycosylase

This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.

Reaction

Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =

Synonyms

G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.29 thymine-DNA glycosylase

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Results	in table
6	Activating Compound
9	AA Sequence
2	Application
1	CAS Registry Number
22	Cloned(Commentary)
10	Crystallization (Commentary)
53	Disease/ Diagnostics
2	Expression
15	General Information
13	Inhibitors
4	KM Value [mM]
9	Localization
2	Metals/Ions
7	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
53	Organism
21	PDB ID
4	pH Optimum
1	pH Range
1	pI Value
4	Posttranslational Modification
22	Protein Variants
21	Purification (Commentary)
1	Reaction
53	Reference
36	Source Tissue
4	Specific Activity [micromol/min/mg]
130	Substrates and Products (Substrate)
9	Subunits
99	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
9	Turnover Number [1/s]

Expression

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Expression on EC 3.2.2.29 - thymine-DNA glycosylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in colorectal cancer patients, enzyme levels are significantly higher in tumor tissues than in the adjacent normal tissues

Homo sapiens

-

732173

wild type p53 binds to a domain of the enzyme promoter containing two p53 consensus response elements and activates its transcription

Homo sapiens

-

731597