3.2.2.29: thymine-DNA glycosylase
This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.
Word Map on EC 3.2.2.29
-
3.2.2.29
-
demethylation
-
5-methylcytosine
-
cytosine
-
deamination
-
glycosylases
-
5-carboxylcytosine
-
mispairs
-
5-formylcytosine
-
5-hydroxymethylcytosine
-
ten-eleven
-
excises
-
uracil-dna
-
abasic
-
methyl-cpg
-
3,n4-ethenocytosine
-
tdg-mediated
-
5-hydroxymethyluracil
-
sumo-1
-
base-excision
-
methyl-cpg-binding
-
medicine
- 3.2.2.29
-
demethylation
- 5-methylcytosine
- cytosine
-
deamination
- glycosylases
- 5-carboxylcytosine
- mispairs
- 5-formylcytosine
-
5-hydroxymethylcytosine
-
ten-eleven
-
excises
-
uracil-dna
-
abasic
-
methyl-cpg
- 3,n4-ethenocytosine
-
tdg-mediated
- 5-hydroxymethyluracil
- sumo-1
-
base-excision
-
methyl-cpg-binding
- medicine
Reaction
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =
Synonyms
G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 3.2.2.29 - thymine-DNA glycosylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
-
additional mismatch located at 3' of T/G have less inhibitory effect on the thymine removal than that located at 5' of T/G. Two additional mismatches located at each side of T/G completely inhibit the excision of thymine
-
additional information
-
no inhibition of TDG activity on methylated G:IU mispairs by the methyl binding domain
-
additional information
sumoylation dramatically impairs the enzyme's base-excision activity, such that guanine-thymine activity is reduced by more than 45fold and 5-formylcytosine and 5-carboxylcytosine are excised slowly, with a reaction half-life of more than 9 min at 37°C
-