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Literature summary for 3.2.2.29 extracted from
- Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs (2009), Cancer Biol. Ther., 8, 1156-1163.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition of TDG activity on methylated G:IU mispairs by the methyl binding domain | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | thymine DNA glycosylase and methyl binding domain protein 4 act on G:IU, i.e. iododeoxyuridine, but not A:IU, mispairs and are functionally complementary to each other | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | thymine DNA glycosylase and methyl binding domain protein 4 act on G:IU, i.e. iododeoxyuridine, but not A:IU, mispairs and are functionally complementary to each other | Homo sapiens | ? | - |
? | |
| additional information | IUdR is a thymidine analogue which has been used in the clinic as a radiosensitizer. Following active cell membrane transport, IUdR is sequentially phosphorylated to IdUTP which competes with thymidine, TdR, for DNA incorporation. G:IU mispair is a substrate for thymidine DNA glycosylase | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
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