3.2.2.29: thymine-DNA glycosylase
This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.
Word Map on EC 3.2.2.29
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3.2.2.29
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demethylation
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5-methylcytosine
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cytosine
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deamination
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glycosylases
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5-carboxylcytosine
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mispairs
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5-formylcytosine
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5-hydroxymethylcytosine
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ten-eleven
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excises
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uracil-dna
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abasic
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methyl-cpg
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3,n4-ethenocytosine
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tdg-mediated
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5-hydroxymethyluracil
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sumo-1
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base-excision
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methyl-cpg-binding
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medicine
- 3.2.2.29
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demethylation
- 5-methylcytosine
- cytosine
-
deamination
- glycosylases
- 5-carboxylcytosine
- mispairs
- 5-formylcytosine
-
5-hydroxymethylcytosine
-
ten-eleven
-
excises
-
uracil-dna
-
abasic
-
methyl-cpg
- 3,n4-ethenocytosine
-
tdg-mediated
- 5-hydroxymethyluracil
- sumo-1
-
base-excision
-
methyl-cpg-binding
- medicine
Reaction
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =
Synonyms
G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase
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General Information on EC 3.2.2.29 - thymine-DNA glycosylase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
physiological function
additional information
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opposing roles of CBP/p300 and PKCalpha in regulating the DNA repair functions of TDG, the interplay of acetylation and phosphorylation of TDG in vivo may be critically important in the maintenance of CpG dinucleotides and epigenetic regulation
malfunction
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enzyme knockdown by shRNAs inhibits the proliferation of colorectal cancer cells in vitro and in vivo
malfunction
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enzyme-knockdown cells exhibit higher resistance to cell death caused by the induction of etheno-DNA adducts, lower repair activityfor 3,N4-ethenocytosine, and a modest acceleration of mutations caused by 3,N4-ethenocytosine,compared with the rate in control cells
malfunction
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enzyme knockdown in melanoma cell lines causes cell cycle arrest, senescence, and death by mitotic alterations, alters the transcriptome and methylome, and impairs xenograft tumor formation
malfunction
the enzyme interacts with the CH3 domain of histone acetyltransferase p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23). The absence of the enzyme in mouse embryonic fibroblasts leads to a reduction in the rate of histone acetylation
physiological function
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TDG plays an integral role in CpG maintenance by excising mispaired thymine and uracil in a CpG context and also participates in transcriptional regulation via gene-specific CpG demethylation and functional interactions with the transcription machinery
physiological function
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TDG seems not to have an important function in uracil repair compared with the leading enzymes UNG2 and SMUG1, EC 3.2.2.27
physiological function
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TDG seems not to have an important function in uracil repair compared with the leading enzymes UNG2 and SMUG1, EC 3.2.2.27
physiological function
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the enzyme does not affect HBV replication, but the hepatitis B virus X-protein strongly inhibits enzyme-initiated base excision repair
physiological function
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the enzyme functions in base excision repair and also acts as a key enzyme that participates in active DNA demethylation. Aberrant enzyme expression causes epigenetic modifications and meiotic cell cycle arrest of mouse oocytes
physiological function
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the enzyme plays key roles in sustaining genome integrity because of its ability to selectively remove thymine from G/T mismatches through the DNA base excision repair pathway. The enzyme is actively involved in epigenetic regulation by participating in the DNA 5-methylcytosine demethylation processes
physiological function
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the enzyme shows repair activities toward etheno-DNA adducts
physiological function
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thymine DNA glycosylase up-regulates Wnt signaling by interacting with the transcription factor TCF4 and coactivator CREB-binding protein/p300 in the Wnt pathway
physiological function
ectopic enzyme expression compromises cellular survival after UV irradiation and repair of UV-induced DNA lesions
physiological function
when enzyme concentrations approach those of histones, the enzyme acts as a competitive inhibitor of p300 histone acetylation
