Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.29 extracted from

  • Visnes, T.; Doseth, B.; Pettersen, H.; Hagen, L.; Sousa, M.; Akbari, M.; Otterlei, M.; Kavli, B.; Slupphaug, G.; Krokan, H.
    Uracil in DNA and its processing by different DNA glycosylases (2009), Philos. Trans. R. Soc. Lond. B Biol. Sci., 364, 563-568.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
AP1 TDG activity is stimulated by APE1 Mus musculus
AP1 TDG activity is stimulated by APE1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus TDG has a strong preference for uracil over thymine. TDG is an intriguing protein that, similar to SMUG1, has a low turnover number and strong binding to AP sites. The binding of the glycosylase to the AP site inhibits cleavage by the downstream AP endonuclease ?
-
?
additional information Homo sapiens TDG has a strong preference for uracil over thymine. TDG is an intriguing protein that, similar to SMUG1, has a low turnover number and strong binding to AP sites. The binding of the glycosylase to the AP site inhibits cleavage by the downstream AP endonuclease ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information TDG catalytic efficiency of the protein is increased by SUMOylation Mus musculus
additional information TDG catalytic efficiency of the protein is increased by SUMOylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information TDG is strictly cell-cycle regulated. TDG is regulated, opposite to UNG2, EC 3.2.2.27, by displaying the highest expression in the G1-phase and the lowest in the S-phase Mus musculus
-
additional information TDG is strictly cell-cycle regulated. TDG is regulated, opposite to UNG2, EC 3.2.2.27, by displaying the highest expression in the G1-phase and the lowest in the S-phase Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
low catalytic turnover of TDG Mus musculus
additional information
-
low catalytic turnover of TDG Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TDG has a strong preference for uracil over thymine. TDG is an intriguing protein that, similar to SMUG1, has a low turnover number and strong binding to AP sites. The binding of the glycosylase to the AP site inhibits cleavage by the downstream AP endonuclease Mus musculus ?
-
?
additional information TDG has a strong preference for uracil over thymine. TDG is an intriguing protein that, similar to SMUG1, has a low turnover number and strong binding to AP sites. The binding of the glycosylase to the AP site inhibits cleavage by the downstream AP endonuclease Homo sapiens ?
-
?
additional information TDG has a strong preference for uracil over thymine, it also has a strong preference for U:G mismatches Mus musculus ?
-
?
additional information TDG has a strong preference for uracil over thymine, it also has a strong preference for U:G mismatches Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
T/U mismatch DNA glycosylase
-
Mus musculus
T/U mismatch DNA glycosylase
-
Homo sapiens
TDG
-
Mus musculus
TDG
-
Homo sapiens

General Information

General Information Comment Organism
physiological function TDG seems not to have an important function in uracil repair compared with the leading enzymes UNG2 and SMUG1, EC 3.2.2.27 Mus musculus
physiological function TDG seems not to have an important function in uracil repair compared with the leading enzymes UNG2 and SMUG1, EC 3.2.2.27 Homo sapiens