3.2.2.29: thymine-DNA glycosylase
This is an abbreviated version!
For detailed information about thymine-DNA glycosylase, go to the full flat file.
Word Map on EC 3.2.2.29
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3.2.2.29
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demethylation
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5-methylcytosine
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cytosine
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deamination
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glycosylases
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5-carboxylcytosine
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mispairs
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5-formylcytosine
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5-hydroxymethylcytosine
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ten-eleven
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excises
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uracil-dna
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abasic
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methyl-cpg
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3,n4-ethenocytosine
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tdg-mediated
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5-hydroxymethyluracil
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sumo-1
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base-excision
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methyl-cpg-binding
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medicine
- 3.2.2.29
-
demethylation
- 5-methylcytosine
- cytosine
-
deamination
- glycosylases
- 5-carboxylcytosine
- mispairs
- 5-formylcytosine
-
5-hydroxymethylcytosine
-
ten-eleven
-
excises
-
uracil-dna
-
abasic
-
methyl-cpg
- 3,n4-ethenocytosine
-
tdg-mediated
- 5-hydroxymethyluracil
- sumo-1
-
base-excision
-
methyl-cpg-binding
- medicine
Reaction
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine. =
Synonyms
G/T glycosylase, G:T mismatch-specific thymine DNA-glycosylase, hsTDG, hTDG, mismatch-specific thymine-DNA glycosylase, mismatch-specific thymine-DNA N-glycosylase, More, Pa-MIG, T/U mismatch DNA glycosylase, T:G mismatch-specific thymidine-DNA glycosylase, TDG, Thd1p, thymine DNA glycosylase, thymine DNA-glycosylase, thymine-DNA glycosylase, uracil/thymine DNA glycosylase
ECTree
3.2.2.29 thymine-DNA glycosylaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.2.2.29 - thymine-DNA glycosylase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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TDG transcripts are uniformly and ubiquitously expressed from 7.5 days post-coitum, but are then markedly enriched in specific tissues of the developing fetus. At 14.5 gestational days, TDG is strongly expressed in the developing nervous system, thymus, lung, liver, kidney and intestine. At later stages, high levels of expression were detected in the thymus, brain, nasal epithelium and within proliferating regions of the intestine, skin, kidney, teeth and bone
additional information
in untransfected MCF-7 cells, endogenous TDG staining is observed in a granular pattern throughout the nucleoplasm. A subpopulation of cells consistently displays increased staining within the promyelocytic leukemia protein oncogenic domains. SUMO-1 binding activity of TDG may be required for targeting to these nuclear structures. Sumoylation of TDG regulates association with CREB-binding protein and subnuclear localization
additional information
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TDG is strictly cell-cycle regulated. TDG is regulated, opposite to UNG2, EC 3.2.2.27, by displaying the highest expression in the G1-phase and the lowest in the S-phase
additional information
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tumors which overexpress MMTV-v-Ha-ras or MMTV-c-myc transgenes or mice heterozygous for p53 gene disruption, all show elevated TDG and methyl transferase expression specific to the transformed tissue
additional information
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TDG is strictly cell-cycle regulated. TDG is regulated, opposite to UNG2, EC 3.2.2.27, by displaying the highest expression in the G1-phase and the lowest in the S-phase
