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3.2.1.45: glucosylceramidase

This is an abbreviated version!
For detailed information about glucosylceramidase, go to the full flat file.

Word Map on EC 3.2.1.45

Reaction

a D-glucosyl-N-acylsphingosine
+
H2O
=
D-glucose
 +
a ceramide

Synonyms

ABG, acid beta-D-glucosidase, acid beta-glucocerebrosidase, acid beta-glucosidase, acid beta-glucosylceramidase, acid beta-glycosidase, acid glucosylceramidase, acid-beta-glucocerebrosidase, acid-beta-glucosidase, Alglucerase, beta-D-glucocerebrosidase, beta-GC, beta-glucocerebrosidase, beta-glucosidase, beta-glucosidase 2, beta-glucosylceramidase, beta-glucosylceramidase 2, beta-glycosylceramidase, bile acid beta-glucosidase, ceramidase, glucosyl-, ceramide glucosidase, cerebroside beta-glucosidase, Ceredase, Cerezyme, D-glucosyl-N-acylsphingosine glucohydrolase, GBA, GBA1, GBA2, Gcase, GCD, GCR, GDA, gene-activated human GlcCerase, Glc-Cerase, glcCer-beta-glucosidase, GlcCerase, glucocerebrosidase, glucocerebroside beta-glucosidase, glucose cerebrosidase, glucosphingosine glucosylhydrolase, glucosylceramidase, glucosylceramide beta-glucosidase, glucosylcerebrosidase, glucosylsphingosine beta-D-glucosidase, glucosylsphingosine beta-glucosidase, glycosylceramidase, glycosylceramide-beta-glucosidase, Imiglucerase, Klotho-related protein, KLrP, lysosomal glucosylceramidase, microsomal bile acid beta-glucosidase, N-acylsphingosyl-1-O-beta-D-glucoside:glucohydrolase, neutral beta-glycosylceramidase, neutral glucosylceramidase, NLGase, non-lysosomal beta-glucosylceramidase, non-lysosomal glucosylceramidase, nonlysosomal beta-glucosidase, nonlysosomal glucosylceramidase, psychosine hydrolase, taliglucerase alfa, velaglucerase alfa, Vpriv

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.45 glucosylceramidase

IC50 Value

IC50 Value on EC 3.2.1.45 - glucosylceramidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0167
(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
Homo sapiens
-
-
0.000015 - 0.0008
(2R,3R,4R,5S)-1-(5-[[3',5'-bis(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0005
(2R,3R,4R,5S)-1-(5-[[4-(1,3-benzodioxol-5-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.00003 - 0.00025
(2R,3R,4R,5S)-1-(5-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000004 - 0.002
(2R,3R,4R,5S)-1-(5-[[4-(2-fluoropyridin-4-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000015 - 0.003
(2R,3R,4R,5S)-1-(5-[[4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000005 - 0.003
(2R,3R,4R,5S)-1-(5-[[4-(6-fluoropyridin-3-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.0003
(2R,3R,4R,5S)-1-[5-(benzyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.00125
(2R,3R,4R,5S)-1-[5-(biphenyl-2-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0003
(2R,3R,4R,5S)-1-[5-(biphenyl-3-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.00001 - 0.000125
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-2,2-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.0003
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-4,4-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0004
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000004 - 0.0015
(2R,3R,4R,5S)-1-[5-(cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.0003
(2R,3R,4R,5S)-1-[5-[(1R)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.4
(2R,3R,4R,5S)-1-[5-[(1S)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0006
(2R,3R,4R,5S)-1-[5-[(2'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.00000008 - 0.0002
(2R,3R,4R,5S)-1-[5-[(2-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.00025
(2R,3R,4R,5S)-1-[5-[(3'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.00000008 - 0.00025
(2R,3R,4R,5S)-1-[5-[(3-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000005 - 0.0005
(2R,3R,4R,5S)-1-[5-[(3beta,17alpha,20S)-cholestan-3-yloxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0005
(2R,3R,4R,5S)-1-[5-[(4'-chlorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.0004
(2R,3R,4R,5S)-1-[5-[(4'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.0001 - 0.0025
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentyl)piperidine-3,4,5-triol
0.00000008 - 0.0001
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[2-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
0.00000012 - 0.0002
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[3-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
0.00001 - 0.0008
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4'-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
0.00001 - 0.003
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyridin-3-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
0.00001 - 0.002
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyridin-4-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
0.000025 - 0.01
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyrimidin-5-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
0.000003 - 0.0005
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(4,6,8a,10c-tetrahydropyren-1-ylmethoxy)pentyl]piperidine-3,4,5-triol
0.000001 - 0.001
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triol
0.0001 - 0.01
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
0.000003 - 0.0006
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(2'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.0000005 - 0.00007
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(2'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.00002 - 0.0025
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(3'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.000002 - 0.00025
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(3'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.00001 - 0.0025
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(4'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.000003 - 0.00025
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(4'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.000003 - 0.0015
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(5-phenylpyridin-2-yl)methoxy]pentyl]piperidine-3,4,5-triol
0.000001 - 0.0004
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(5R)-octahydro-1H-2,5-methanoinden-6-ylmethoxy]pentyl]piperidine-3,4,5-triol
0.000002 - 0.0001
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]hexyl]piperidine-3,4,5-triol
0.00001 - 0.00006
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]hexyl]piperidine-3,4,5-triol
0.0003 - 0.32
(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.2
(2R,3S,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.0002
(2R,3S,4R,5S)-2-(hydroxymethyl)-1-[5-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]pentyl]piperidine-3,4,5-triol
0.00025
(2S,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
Homo sapiens
isoform GBA2, pH and temperature not specified in the publication
0.000001 - 0.015
(2S,3R,4R,5S)-1-[5-(8a,10c-dihydropyren-1-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.01
(2S,3R,4R,5S)-1-[5-(benzyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.015
(2S,3R,4R,5S)-1-[5-(biphenyl-2-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.02
(2S,3R,4R,5S)-1-[5-(biphenyl-3-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.5
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-2,2-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.0125
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-4,4-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000003 - 0.02
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000006 - 0.06
(2S,3R,4R,5S)-1-[5-(cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000001 - 0.01
(2S,3R,4R,5S)-1-[5-[(1R)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000002 - 0.01
(2S,3R,4R,5S)-1-[5-[(1S)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.0000006 - 0.006
(2S,3R,4R,5S)-1-[5-[(2-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.0000004 - 0.008
(2S,3R,4R,5S)-1-[5-[(3-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.000005 - 0.015
(2S,3R,4R,5S)-1-[5-[(3beta,17alpha,20S)-cholest-5-en-3-yloxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
0.0001 - 0.05
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentyl)piperidine-3,4,5-triol
0.0000001 - 0.006
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[2-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
0.0000001 - 0.005
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[3-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
0.000008 - 0.012
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[(5Z)-6-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]hex-5-en-1-yl]piperidine-3,4,5-triol
0.000001 - 0.05
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triol
0.0002 - 0.6
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
0.000002 - 0.01
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(1R,5S)-tricyclo[3.3.1.13,7]dec-2-ylmethoxy]pentyl]piperidine-3,4,5-triol
0.0000025 - 0.005
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]hexyl]piperidine-3,4,5-triol
0.00002 - 0.025
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3S)-tricyclo[3.3.1.13,7]dec-1-yl]hexyl]piperidine-3,4,5-triol
0.00001 - 0.00004
(3aR,4S,5R,6R,7S,7aS)-2-(3-phenylpropylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
0.000004 - 0.00001
(3aR,4S,5R,6R,7S,7aS)-2-(nonylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
0.0017 - 0.006
(3aR,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0012 - 0.0104
(3aR,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00032 - 0.0019
(3aR,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0567 - 0.16
(3aR,4S,5R,6S,7R,7aS)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0173
(3aR,4S,5S,6S,7R,7aR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.157
(3aR,4S,5S,6S,7R,7aR)-4-(benzyloxy)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.0044 - 0.0129
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00019 - 0.00071
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00054 - 0.0025
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0006 - 0.0029
(3aRS,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0644
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.0013
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.0064
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.00002 - 0.00012
(3aS,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0056 - 0.0111
(3aS,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.000005 - 0.000008
(3aS,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0024 - 0.0068
(3aS,4S,5R,6S,7R,7aS)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00035
(3aS,4S,5S,6S,7R,7aS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.0016 - 0.0064
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00004 - 0.00022
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00008 - 0.0006
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00004 - 0.0001
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.000008 - 0.000009
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.00001 - 0.0002
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
0.0039
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.0017
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.00074
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
Homo sapiens
-
pH 5.2, 37°C
0.1
(3R,4R,5R)-5-(hydroxymethyl)-1-octylpiperidine-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000043 - 0.0000057
(3R,4S,5S)-5-(nonyloxy)piperidine-3,4-diol
0.000009
(3R,4S,5S)-5-(pentyloxy)piperidine-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000043 - 0.0000048
(3R,4S,5S)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0000199 - 0.0000243
(3R,4S,5S)-5-[[1-(10-hydroxydecyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.000182 - 0.000292
(3R,4S,5S)-5-[[1-(6-hydroxyhexyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.0000033 - 0.0000036
(3R,4S,5S,3'R,4'S,5'S)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
0.000075 - 0.042
(3S,4R,5R)-5-(nonyloxy)piperidine-3,4-diol
0.0016
(3S,4R,5R)-5-(pentyloxy)piperidine-3,4-diol
Homo sapiens
pH and temperature not specified in the publication
0.0000285 - 0.0000571
(3S,4R,5R)-5-([1-[6-([5-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]pentyl]oxy)hexyl]-1H-1,2,3-triazol-4-yl]methoxy)piperidine-3,4-diol
0.019 - 0.058
(3S,4R,5R)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0000236 - 0.0000325
(3S,4R,5R)-5-[(1-[10-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]decyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.000017 - 0.000046
(3S,4R,5R)-5-[(1-[22-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]-3,6,9,12-tetraoxadocosan-1-yl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.000223 - 0.0018
(3S,4R,5R)-5-[(1-[6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.059 - 0.129
(3S,4R,5R)-5-[[1-(2,5,8,11-tetraoxatridecan-13-yl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.000362 - 0.0011
(3S,4R,5R)-5-[[1-(2-[2-[2-([6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]oxy)ethoxy]ethoxy]ethyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.094 - 0.162
(3S,4R,5R,3'S,4'R,5'R)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
0.00587
(R)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00043
(S)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.16
1,4-dideoxy-1,4-imino-D-arabinitol
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0023
1,5-dideoxy-1,5-iminoxylitol
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0068
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)-3-phenylpropan-2-ol
Homo sapiens
-
-
0.0207
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)propan-2-ol
Homo sapiens
-
-
0.0288 - 0.506
1-deoxynojirimycin
0.00071
1-[3-[(5-bromopyridin-2-yl)(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Homo sapiens
-
pH 5.9, at 22°C
0.00043 - 0.0007
2-(4-(5-chloro-2-methoxyphenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol
0.0000099
2-(pyridin-3-yl)-N-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.0000087
2-(pyridin-3-yl)-N-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.0075
2-([4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0188
2-([4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0061
2-([4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00231
2-([4-azetidin-1-yl-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0049
2-([4-[(2,4-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00153
2-([4-[(2,5-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.02897
2-([4-[(2-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00077
2-([4-[(2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.002
2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
Homo sapiens
-
-
0.00108
2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00394
2-([4-[(2-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0314
2-([4-[(2-phenoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00104
2-([4-[(2-tert-butoxy-5-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00033
2-([4-[(2-tert-butoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00669
2-([4-[(3-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00825
2-([4-[(3-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0477
2-([4-[(3-methylphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00431 - 0.00619
2-([4-[(3-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0465
2-([4-[(4-chlorophenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00634 - 0.00773
2-([4-[(4-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0088
2-([4-[(4-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.01004
2-([4-[(4-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00222
2-([4-[(5-benzyl-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00096
2-([4-[(5-chloro-2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0004
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
pH 5.9, at 22°C
0.01213
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.0311
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-piperidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
Homo sapiens
-
-
0.00334
2-[(4-pyrrolidin-1-yl-6-[[2-(trifluoromethoxy)phenyl]amino]-1,3,5-triazin-2-yl)amino]ethanol
Homo sapiens
-
-
0.02167
2-[(4-[[2-(benzyloxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
Homo sapiens
-
-
0.00239
2-[(4-[[2-(methylsulfanyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
Homo sapiens
-
-
0.00265
2-[(4-[[2-methoxy-5-(trifluoromethyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
Homo sapiens
-
-
0.00344
2-[(4-[[5-chloro-2-(1-methylethoxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
Homo sapiens
-
-
0.01647
2-[[4-(phenylamino)-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]ethanol
Homo sapiens
-
-
0.28
2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.000005 - 0.0006
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-2-carbonitrile
0.000002 - 0.0007
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-3-carbonitrile
0.000003 - 0.00035
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-4-carbonitrile
0.00037
4-benzyl-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
Homo sapiens
-
-
0.00073
4-chloro-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
Homo sapiens
-
-
0.000063
4-methyl-N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)cyclohexanecarboxamide
Homo sapiens
-
-
0.000452
4-methyl-N-(4-methyl-2-piperidin-1-ylquinolin-6-yl)cyclohexanecarboxamide
Homo sapiens
-
-
0.000268
4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)quinolin-6-yl]cyclohexanecarboxamide
Homo sapiens
-
-
0.00245
4-methyl-N-[4-methyl-2-(4-pyrimidin-4-ylpiperazin-1-yl)-1,2-dihydroquinolin-6-yl]cyclohexanecarboxamide
Homo sapiens
-
-
0.000075 - 0.00165
4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
0.0089
4-[4-(naphthalen-2-ylsulfonyl)piperazin-1-yl]-2-(thiophen-2-yl)quinazoline
Homo sapiens
-
pH 5.9, at 22°C
0.00129
4-[[(4-chlorophenyl)sulfonyl]amino]-N-(2,5-dihydro-1,3-thiazol-2-yl)benzamide
Homo sapiens
-
-
0.0078
5-((4-methylphenyl)thio)-quinazoline 2,4-diamine
Homo sapiens
-
pH 5.5, 37°C
0.0047
5-(3,5-dichlorophenoxy)-N-(4-pyridinyl)-2-furamide
Homo sapiens
-
pH 5.5, 37°C
0.1
alpha-1-C-butyl-1-deoxynojirimycin
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.000019
alpha-1-C-hexyl-1-deoxyimino-D-xylitol
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.0042
alpha-1-C-hexyl-1-deoxynojirimycin
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.00056
alpha-1-C-propyl-1-deoxyimino-D-xylitol
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.4
alpha-1-C-propyl-1-deoxynojirimycin
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.147
beta-1-C-butyl-1,5-dideoxy-1,5-imino-L-iditol
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.043
beta-1-C-hexyl-1,5-dideoxy-1,5-imino-L-iditol
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.487
beta-1-C-propyl-1,5-dideoxy-1,5-imino-L-iditol
Homo sapiens
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.0031
calystegine A3
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.031
calystegine A5
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0025
calystegine B1
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.001
calystegine B2
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.076
calystegine B3
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.082
calystegine B4
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0025
calystegine C1
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.019
castanospermine
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.009497
conduritol beta-epoxide
Homo sapiens
at pH 5.2 and 37°C
0.000005 - 0.2
isofagomine
0.00188
N-(1-phenoxypropan-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.0000083
N-(2,3-dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00214
N-(2,3-dihydro-1H-inden-2-yl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.0344
N-(2,5-dihydro-1,3-thiazol-2-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.0073
N-(2-(benzyloxy)ethyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00424
N-(2-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00097
N-(2-phenylethyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00254
N-(3-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00178
N-(3-phenylpropyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.000133
N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)-4-propylcyclohexanecarboxamide
Homo sapiens
-
-
0.000183
N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)cyclopropanecarboxamide
Homo sapiens
-
-
0.000031
N-(4-methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide
Homo sapiens
-
-
0.00128
N-(4-phenylbutyl)-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00007 - 0.000103
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-(phenylsulfonamido)benzamide
0.0001
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-[(phenylsulfonyl)amino]benzamide
Homo sapiens
-
pH 5.9, at 22°C
0.00296
N-(5-ethyl-1,3,4-thiadiazolidin-2-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.000168
N-(5-methylisoxazol-3-yl)-4-(phenylsulfonamido)benzamide
Homo sapiens
-
-
0.0252
N-(5-methylisoxazol-3-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.1
N-benzyl-4-[(phenylsulfonyl)amino]benzamide
Homo sapiens
-
IC50 above 0.1 mM
0.27
N-butyl-1-deoxynojirimycin
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-glucopyranoside as substrate
0.0246
N-butyl-4-[(phenylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.044
N-butyl-isofagomine
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.00777
N-butyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
-
0.002
N-butyldeoxynojirimycin
Homo sapiens
-
in 50 mM citrate buffer with 0.25% (v/v) Triton X-100 (pH 4.5)
0.00014
N-carboxy-nonyldeoxynojirimycin
Mus musculus
-
-
0.000042
N-cycloheptyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00994
N-cycloheptyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.000177
N-cyclohexyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.000027
N-cyclooctyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00838
N-cyclooctyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00072
N-cyclopentyl-2-(pyridin-3-yl)quinazolin-4-amine
Homo sapiens
at pH 5.0 and 25°C
0.00005
N-dodecyl-1-deoxynojirimycin
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0229
N-dodecyl-deoxynojirimycin
Mus musculus
-
-
0.32
N-methyl-calystegine B2
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.0003 - 0.00066
N-nonyl-deoxynojirimycin
0.00646
N-phenyl-4-[(phenylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.000009 - 0.0005
N-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]-6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamide
0.000015 - 0.04
N-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]-6-[(2S,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamide
0.00003
N-[2-(3,6-dihydropyridin-1(2H)-yl)-4-methylquinolin-6-yl]cyclohexanecarboxamide
Homo sapiens
-
pH 5.9, at 22°C
0.00106
N-[2-(diethylamino)-4-methyl-1,2-dihydroquinolin-6-yl]-4-methylcyclohexanecarboxamide
Homo sapiens
-
-
0.000001 - 0.002
N-[5-(adamantan-1-yl-methoxy)pentyl]-L-ido-1-deoxynojirimycin
0.00002 - 0.00035
N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
0.028
nojirimycin bisulfite
Homo sapiens
-
in 0.1 M citrate buffer (pH 5.2), using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate
0.005458
triazole-linked 6-BODIPY-2-deoxy-2-fluoro-beta-D-glucopyranosyl-N-phenyltrifluoroacetimidate inhibitor
Homo sapiens
at pH 5.2 and 37°C
-