Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isofagomine | GlcCerase activity is enhanced in normal fibroblasts 1.3fold after treatment with 0.03 mM isofagomine for 5 days | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N370S | decreased activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isofagomine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCD-43Sk cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-beta-D-glucopyranoside + H2O | - |
Homo sapiens | methylumbelliferone + beta-D-glucose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GlcCerase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
wild type enzyme, at pH 7.2 | Homo sapiens | isofagomine | |
0.000009 | - |
wild type enzyme, at pH 6.4 | Homo sapiens | isofagomine | |
0.000018 | - |
mutant enzyme N370S, at pH 5.2 | Homo sapiens | isofagomine | |
0.000026 | - |
mutant enzyme N370S, at pH 6.4 | Homo sapiens | isofagomine | |
0.00003 | - |
wild type enzyme, at pH 5.2 | Homo sapiens | isofagomine | |
0.000128 | - |
mutant enzyme N370S, at pH 7.2 | Homo sapiens | isofagomine |