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3.2.1.45: glucosylceramidase

This is an abbreviated version!
For detailed information about glucosylceramidase, go to the full flat file.

Word Map on EC 3.2.1.45

Reaction

a D-glucosyl-N-acylsphingosine
+
H2O
=
D-glucose
 +
a ceramide

Synonyms

ABG, acid beta-D-glucosidase, acid beta-glucocerebrosidase, acid beta-glucosidase, acid beta-glucosylceramidase, acid beta-glycosidase, acid glucosylceramidase, acid-beta-glucocerebrosidase, acid-beta-glucosidase, Alglucerase, beta-D-glucocerebrosidase, beta-GC, beta-glucocerebrosidase, beta-glucosidase, beta-glucosidase 2, beta-glucosylceramidase, beta-glucosylceramidase 2, beta-glycosylceramidase, bile acid beta-glucosidase, ceramidase, glucosyl-, ceramide glucosidase, cerebroside beta-glucosidase, Ceredase, Cerezyme, D-glucosyl-N-acylsphingosine glucohydrolase, GBA, GBA1, GBA2, Gcase, GCD, GCR, GDA, gene-activated human GlcCerase, Glc-Cerase, glcCer-beta-glucosidase, GlcCerase, glucocerebrosidase, glucocerebroside beta-glucosidase, glucose cerebrosidase, glucosphingosine glucosylhydrolase, glucosylceramidase, glucosylceramide beta-glucosidase, glucosylcerebrosidase, glucosylsphingosine beta-D-glucosidase, glucosylsphingosine beta-glucosidase, glycosylceramidase, glycosylceramide-beta-glucosidase, Imiglucerase, Klotho-related protein, KLrP, lysosomal glucosylceramidase, microsomal bile acid beta-glucosidase, N-acylsphingosyl-1-O-beta-D-glucoside:glucohydrolase, neutral beta-glycosylceramidase, neutral glucosylceramidase, NLGase, non-lysosomal beta-glucosylceramidase, non-lysosomal glucosylceramidase, nonlysosomal beta-glucosidase, nonlysosomal glucosylceramidase, psychosine hydrolase, taliglucerase alfa, velaglucerase alfa, Vpriv

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.45 glucosylceramidase

KI Value

KI Value on EC 3.2.1.45 - glucosylceramidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0003
(1R,2S,3r,4R,5S,6s)-6-(nonylamino)cyclohexane-1,2,3,4,5-pentol
pH and temperature not specified in the publication
0.00033
(1R,2S,3r,4R,5S,6s)-6-[[(1-octyl-1H-1,2,3-triazol-4-yl)methyl]amino]cyclohexane-1,2,3,4,5-pentol
pH and temperature not specified in the publication
0.0000022
(2R,3S,4S,5R)-2-octylpiperidine-3,4,5-triol
pH and temperature not specified in the publication
0.00001
(3aR,4S,5R,6R,7S,7aS)-2-(3-phenylpropylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.000003
(3aR,4S,5R,6R,7S,7aS)-2-(nonylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0018
(3aR,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0048
(3aR,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0015
(3aR,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0088
(3aR,4S,5S,6S,7R,7aR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.0111
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.00044
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0017
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0024
(3aRS,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0259
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.00053
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.0036
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.00004
(3aS,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0125
(3aS,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.000002
(3aS,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0028
(3aS,4S,5R,6S,7R,7aS)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.00018
(3aS,4S,5S,6S,7R,7aS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.0034
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.00007
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.00023
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.00004
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.000002
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.000007
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
pH 5.2, 37°C
0.0013
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.00047
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.00013
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
pH 5.2, 37°C
0.0000084 - 0.000025
(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol
pH and temperature not specified in the publication
0.0005
(3R,4R,5S)-1-nonylpiperidine-3,4,5-triol
pH and temperature not specified in the publication
0.0019
(3R,4R,5S)-piperidine-3,4,5-triol
pH and temperature not specified in the publication
0.0000017 - 0.0000023
(3R,4S,5S)-5-(nonyloxy)piperidine-3,4-diol
0.0000021 - 0.0000067
(3R,4S,5S)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0000082 - 0.0000133
(3R,4S,5S)-5-[[1-(10-hydroxydecyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.00016 - 0.000341
(3R,4S,5S)-5-[[1-(6-hydroxyhexyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.0000016 - 0.0000021
(3R,4S,5S,3'R,4'S,5'S)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
0.0423 - 0.069
(3S,4R,5R)-5-(nonyloxy)piperidine-3,4-diol
0.0000278 - 0.0000289
(3S,4R,5R)-5-([1-[6-([5-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]pentyl]oxy)hexyl]-1H-1,2,3-triazol-4-yl]methoxy)piperidine-3,4-diol
0.015 - 0.071
(3S,4R,5R)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0000199 - 0.0000216
(3S,4R,5R)-5-[(1-[10-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]decyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0000073 - 0.0000252
(3S,4R,5R)-5-[(1-[22-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]-3,6,9,12-tetraoxadocosan-1-yl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.0001642 - 0.0031
(3S,4R,5R)-5-[(1-[6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
0.059 - 0.144
(3S,4R,5R)-5-[[1-(2,5,8,11-tetraoxatridecan-13-yl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.00026 - 0.000391
(3S,4R,5R)-5-[[1-(2-[2-[2-([6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]oxy)ethoxy]ethoxy]ethyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
0.000225 - 0.137
(3S,4R,5R,3'S,4'R,5'R)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
0.0057 - 0.0069
(3S,4S,5S)-5-(hydroxymethyl)piperidine-3,4-diol
pH and temperature not specified in the publication
2.4
2-deoxy-2-fluoro-beta-D-glucopyranoside
-
pH 6.5, 37°C
2.2
alpha-1-C-nonyl-1-deoxyimino-D-xylitol
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C
0.0005 - 0.0015
calystegine B1
0.0009
calystegine C1
-
pH 4.5, 37°C
8.1
conduritol B epoxide
pH and temperature not specified in the publication
0.0003
N-nonyl-deoxynojirimycin
-
pH 5.2, 37°C
1.7
p-nitrophenyl beta-D-glucopyranoside
-
pH 6.5, 37°C, mutant D223G