3.2.1.45: glucosylceramidase

This is an abbreviated version!
For detailed information about glucosylceramidase, go to the full flat file.

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Synonyms

ABG, acid beta-D-glucosidase, acid beta-glucocerebrosidase, acid beta-glucosidase, acid beta-glucosylceramidase, acid beta-glycosidase, acid glucosylceramidase, acid-beta-glucocerebrosidase, acid-beta-glucosidase, Alglucerase, beta-D-glucocerebrosidase, beta-GC, beta-glucocerebrosidase, beta-glucosidase, beta-glucosidase 2, beta-glucosylceramidase, beta-glucosylceramidase 2, beta-glycosylceramidase, bile acid beta-glucosidase, ceramidase, glucosyl-, ceramide glucosidase, cerebroside beta-glucosidase, Ceredase, Cerezyme, D-glucosyl-N-acylsphingosine glucohydrolase, GBA, GBA1, GBA2, Gcase, GCD, GCR, GDA, gene-activated human GlcCerase, Glc-Cerase, glcCer-beta-glucosidase, GlcCerase, glucocerebrosidase, glucocerebroside beta-glucosidase, glucose cerebrosidase, glucosphingosine glucosylhydrolase, glucosylceramidase, glucosylceramide beta-glucosidase, glucosylcerebrosidase, glucosylsphingosine beta-D-glucosidase, glucosylsphingosine beta-glucosidase, glycosylceramidase, glycosylceramide-beta-glucosidase, Imiglucerase, Klotho-related protein, KLrP, lysosomal glucosylceramidase, microsomal bile acid beta-glucosidase, N-acylsphingosyl-1-O-beta-D-glucoside:glucohydrolase, neutral beta-glycosylceramidase, neutral glucosylceramidase, NLGase, non-lysosomal beta-glucosylceramidase, non-lysosomal glucosylceramidase, nonlysosomal beta-glucosidase, nonlysosomal glucosylceramidase, psychosine hydrolase, taliglucerase alfa, velaglucerase alfa, Vpriv

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.45 glucosylceramidase

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Results	in table
108	Activating Compound
6073	AA Sequence
31	Application
1	CAS Registry Number
40	Cloned(Commentary)
9	Crystallization (Commentary)
5372	Disease/ Diagnostics
14	General Information
11	General Stability
366	IC50 Value
434	Inhibitors
9	kcat/KM [mM/s]
70	Ki Value [mM]
65	KM Value [mM]
46	Localization
30	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
153	Organism
1	Oxidation Stability
3	Pathway
113	PDB ID
23	pH Optimum
7	pH Range
4	pH Stability
2	pI Value
9	Posttranslational Modification
169	Protein Variants
36	Purification (Commentary)
2	Reaction
1	Reaction Type
150	Reference
143	Source Tissue
30	Specific Activity [micromol/min/mg]
4	Storage Stability
214	Substrates and Products (Substrate)
14	Subunits
209	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
8	Temperature Stability [°C]
20	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.2.1.45 - glucosylceramidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

beta-glucosylceramide + H2O

D-glucose + ceramide

Homo sapiens

P04062, Q9HCG7

-

749981

-

-

?

D-glucosylceramide + H2O

D-glucose + ceramide

Mus musculus

Q69ZF3

-

751127

-

-

?

D-glucosylsphingosine + H2O

?

Homo sapiens

P04062, Q9HCG7

-

749981

-

-

?

glucocerebroside + H2O

ceramide + D-glucose

Homo sapiens

-

-

729444, 730593, 730830

-

-

?

glucocerebroside + H2O

D-glucose + ceramide

2 entries

glucocerebroside + H2O

glucose + ceramide

6 entries

glucosylceramide + H2O

beta-D-glucose + ceramide

4 entries

glucosylceramide + H2O

D-glucose + ceramide

Homo sapiens

P04062

-

749459

-

-

?

glucosyllysosphingosine + H2O

?

Thermoanaerobacterium xylanolyticum

F6BL85

-

749456

-

-

?

additional information

?

-

2 entries

glucocerebroside + H2O

D-glucose + ceramide

Homo sapiens

P04062

-

751573

-

-

?

glucocerebroside + H2O

D-glucose + ceramide

Homo sapiens

Q9HCG7

-

751699

-

-

?

glucocerebroside + H2O

glucose + ceramide

Bos taurus

-

-

136453, 136455, 136468, 136471, 136472

-

-

?

glucocerebroside + H2O

glucose + ceramide

Homo sapiens

-

-

136450, 136452, 136453, 136456, 136458, 136459, 136462, 136463, 136464, 136465, 136469, 136470, 136471, 136473, 136474, 136475, 136476, 136477, 136478, 136479, 136483, 136484, 136486

-

-

?

glucocerebroside + H2O

glucose + ceramide

Homo sapiens

P04062

-

136487

-

-

?

glucocerebroside + H2O

glucose + ceramide

Mus musculus

-

-

136449, 136453, 136471, 136480, 136481

-

-

?

glucocerebroside + H2O

glucose + ceramide

Rattus norvegicus

-

-

136448, 136453, 136463, 136471

-

-

?

glucocerebroside + H2O

glucose + ceramide

Sus scrofa

-

-

136453, 136471

-

-

?

glucosylceramide + H2O

beta-D-glucose + ceramide

Homo sapiens

-

-

702685, 702686, 702852, 702969, 703964, 730162

-

-

?

glucosylceramide + H2O

beta-D-glucose + ceramide

Homo sapiens

P04062

-

751780

-

-

?

glucosylceramide + H2O

beta-D-glucose + ceramide

Thermoanaerobacterium xylanolyticum

F6BL85

-

749456

-

-

?

glucosylceramide + H2O

beta-D-glucose + ceramide

Thermoanaerobacterium xylanolyticum GH116

F6BL85

-

749456

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme catalyses the penultimate step in the breakdown of membrane glycosphingolipids

657256

-

-

?

additional information

?

-

Homo sapiens

-

point mutations in glucocerebrosidase can cause Gaucher disease, a common lysosomal storage disease

663458

-

-

?