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3.2.1.45: glucosylceramidase

This is an abbreviated version!
For detailed information about glucosylceramidase, go to the full flat file.

Word Map on EC 3.2.1.45

Reaction

a D-glucosyl-N-acylsphingosine
+
H2O
=
D-glucose
 +
a ceramide

Synonyms

ABG, acid beta-D-glucosidase, acid beta-glucocerebrosidase, acid beta-glucosidase, acid beta-glucosylceramidase, acid beta-glycosidase, acid glucosylceramidase, acid-beta-glucocerebrosidase, acid-beta-glucosidase, Alglucerase, beta-D-glucocerebrosidase, beta-GC, beta-glucocerebrosidase, beta-glucosidase, beta-glucosidase 2, beta-glucosylceramidase, beta-glucosylceramidase 2, beta-glycosylceramidase, bile acid beta-glucosidase, ceramidase, glucosyl-, ceramide glucosidase, cerebroside beta-glucosidase, Ceredase, Cerezyme, D-glucosyl-N-acylsphingosine glucohydrolase, GBA, GBA1, GBA2, Gcase, GCD, GCR, GDA, gene-activated human GlcCerase, Glc-Cerase, glcCer-beta-glucosidase, GlcCerase, glucocerebrosidase, glucocerebroside beta-glucosidase, glucose cerebrosidase, glucosphingosine glucosylhydrolase, glucosylceramidase, glucosylceramide beta-glucosidase, glucosylcerebrosidase, glucosylsphingosine beta-D-glucosidase, glucosylsphingosine beta-glucosidase, glycosylceramidase, glycosylceramide-beta-glucosidase, Imiglucerase, Klotho-related protein, KLrP, lysosomal glucosylceramidase, microsomal bile acid beta-glucosidase, N-acylsphingosyl-1-O-beta-D-glucoside:glucohydrolase, neutral beta-glycosylceramidase, neutral glucosylceramidase, NLGase, non-lysosomal beta-glucosylceramidase, non-lysosomal glucosylceramidase, nonlysosomal beta-glucosidase, nonlysosomal glucosylceramidase, psychosine hydrolase, taliglucerase alfa, velaglucerase alfa, Vpriv

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.45 glucosylceramidase

Inhibitors

Inhibitors on EC 3.2.1.45 - glucosylceramidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
(1R,2S,3r,4R,5S,6s)-6-(nonylamino)cyclohexane-1,2,3,4,5-pentol
-
(1R,2S,3r,4R,5S,6s)-6-[[(1-octyl-1H-1,2,3-triazol-4-yl)methyl]amino]cyclohexane-1,2,3,4,5-pentol
-
(2R,3R,4R,5S)-1-(5-[[3',5'-bis(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-(5-[[4-(1,3-benzodioxol-5-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-(5-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-(5-[[4-(2-fluoropyridin-4-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-(5-[[4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-(5-[[4-(6-fluoropyridin-3-yl)benzyl]oxy]pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(benzyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(biphenyl-2-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(biphenyl-3-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-2,2-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-4,4-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-(hexyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(1R)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(1S)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(2'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(2-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(3'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(3-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(3beta,17alpha,20S)-cholestan-3-yloxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(4'-chlorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-1-[5-[(4'-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[2-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[3-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4'-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyridin-3-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyridin-4-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[4-(pyrimidin-5-yl)benzyl]oxy]pentyl)piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(4,6,8a,10c-tetrahydropyren-1-ylmethoxy)pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(2'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(2'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(3'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(3'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(4'-methoxybiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(4'-methylbiphenyl-4-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(5-phenylpyridin-2-yl)methoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(5R)-octahydro-1H-2,5-methanoinden-6-ylmethoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]hexyl]piperidine-3,4,5-triol
-
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]hexyl]piperidine-3,4,5-triol
-
(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3S,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2R,3S,4R,5S)-2-(hydroxymethyl)-1-[5-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]pentyl]piperidine-3,4,5-triol
-
(2R,3S,4S,5R)-2-octylpiperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(8a,10c-dihydropyren-1-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(benzyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(biphenyl-2-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(biphenyl-3-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-2,2-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)-4,4-difluoropentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(biphenyl-4-ylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-(hexyloxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-[(1R)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-[(1S)-1-(biphenyl-4-yl)ethoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-[(2-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-[(3-fluorobiphenyl-4-yl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-1-[5-[(3beta,17alpha,20S)-cholest-5-en-3-yloxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[2-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-(5-[[3-(trifluoromethyl)biphenyl-4-yl]methoxy]pentyl)piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[(5Z)-6-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]hex-5-en-1-yl]piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[5-[(1R,5S)-tricyclo[3.3.1.13,7]dec-2-ylmethoxy]pentyl]piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3R)-tricyclo[3.3.1.13,7]dec-1-ylmethoxy]hexyl]piperidine-3,4,5-triol
-
(2S,3R,4R,5S)-2-(hydroxymethyl)-1-[6-[(3S)-tricyclo[3.3.1.13,7]dec-1-yl]hexyl]piperidine-3,4,5-triol
-
(3aR,4S,5R,6R,7S,7aS)-2-(3-phenylpropylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
-
-
(3aR,4S,5R,6R,7S,7aS)-2-(nonylimino)-octahydro-1H-benzo[d]imidazole-4,5,6,7-tetraol
-
-
(3aR,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aR,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aR,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aR,4S,5R,6S,7R,7aS)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aR,4S,5S,6S,7R,7aR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aR,4S,5S,6S,7R,7aR)-4-(benzyloxy)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aRS,4SR,5RS,6SR,7RS,7aRS)- 2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aRS,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aRS,4SR,5SR,6SR,7RS,7aRS)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aS,4S,5R,6S,7R,7aR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aS,4S,5R,6S,7R,7aR)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aS,4S,5R,6S,7R,7aS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aS,4S,5R,6S,7R,7aS)-3-nonyl-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aS,4S,5S,6S,7R,7aS)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aRS)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(hexylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(nonylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5RS,6SR,7RS,7aSR)-2-(octylimino)-octahydrobenzo[d]oxazole-4,5,6,7-tetraol
-
-
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(hexylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(nonylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3aSR,4SR,5SR,6SR,7RS,7aSR)-4-(benzyloxy)-2-(octylimino)-octahydrobenzo[d]oxazole-5,6,7-triol
-
-
(3R,4R,5R)-1-heptyl-5-(hydroxymethyl)piperidine-3,4-diol
-
(3R,4R,5R)-5-(hydroxymethyl)-1-octylpiperidine-3,4-diol
-
(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol
-
(3R,4R,5S)-1-nonylpiperidine-3,4,5-triol
-
(3R,4R,5S)-piperidine-3,4,5-triol
-
(3R,4S,5S)-5-(nonyloxy)piperidine-3,4-diol
-
(3R,4S,5S)-5-(pentyloxy)piperidine-3,4-diol
-
(3R,4S,5S)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
-
(3R,4S,5S)-5-[[1-(10-hydroxydecyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
-
(3R,4S,5S)-5-[[1-(6-hydroxyhexyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
-
(3R,4S,5S,3'R,4'S,5'S)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
-
(3S,4R,5R)-5-(nonyloxy)piperidine-3,4-diol
-
(3S,4R,5R)-5-(pentyloxy)piperidine-3,4-diol
-
(3S,4R,5R)-5-([1-[6-([5-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]pentyl]oxy)hexyl]-1H-1,2,3-triazol-4-yl]methoxy)piperidine-3,4-diol
-
(3S,4R,5R)-5-[(1-nonyl-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
-
(3S,4R,5R)-5-[(1-[10-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]decyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
-
(3S,4R,5R)-5-[(1-[22-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]-3,6,9,12-tetraoxadocosan-1-yl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
-
(3S,4R,5R)-5-[(1-[6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]-1H-1,2,3-triazol-4-yl)methoxy]piperidine-3,4-diol
-
(3S,4R,5R)-5-[[1-(2,5,8,11-tetraoxatridecan-13-yl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
-
(3S,4R,5R)-5-[[1-(2-[2-[2-([6-[4-([[(3S,4S,5R)-4,5-dihydroxypiperidin-3-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]hexyl]oxy)ethoxy]ethoxy]ethyl)-1H-1,2,3-triazol-4-yl]methoxy]piperidine-3,4-diol
-
(3S,4R,5R,3'S,4'R,5'R)-5,5'-[3,6,9,12-tetraoxadocosane-1,22-diylbis[(1H-1,2,3-triazole-1,4-diyl)methyleneoxy]]di(piperidine-3,4-diol)
-
(3S,4S,5S)-5-(hydroxymethyl)piperidine-3,4-diol
-
(R)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine
-
(S)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine
-
1,4-dideoxy-1,4-imino-D-arabinitol
-
-
1,5-dideoxy-1,5-iminoxylitol
-
potent inhibitor
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)-3-phenylpropan-2-ol
-
-
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)propan-2-ol
-
-
1-deoxynojirimycin
1-[3-[(5-bromopyridin-2-yl)(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
-
-
2,2'-([4-[(5-chloro-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]imino)diethanol
-
-
2,4-dinitrophenyl 2-deoxy-2-fluoro-beta-D-glucoside
-
2-(4-(5-chloro-2-methoxyphenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol
-
-
2-(pyridin-3-yl)-N-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine
-
2-(pyridin-3-yl)-N-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine
-
2-([4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-azetidin-1-yl-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2,4-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2,5-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)benzamide
-
-
2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
-
2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)acetamide
-
-
2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-nitrophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-phenoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-tert-butoxy-5-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(2-tert-butoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(3-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(3-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(3-methylphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(3-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(4-chlorophenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(4-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(4-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(4-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-benzyl-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-(diethylamino)-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-azepan-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-piperidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
-
2-deoxy-2-fluoro-beta-D-glucopyranoside
-
-
2-[(4-pyrrolidin-1-yl-6-[[2-(trifluoromethoxy)phenyl]amino]-1,3,5-triazin-2-yl)amino]ethanol
-
-
2-[(4-[[2-(benzyloxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
-
2-[(4-[[2-(methylsulfanyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
-
2-[(4-[[2-methoxy-5-(trifluoromethyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
-
2-[(4-[[5-chloro-2-(1-methylethoxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
-
2-[[4-(phenylamino)-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]ethanol
-
-
2-[[4-(prop-2-en-1-ylamino)-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]ethanol
-
-
2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine
-
-
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-2-carbonitrile
-
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-3-carbonitrile
-
4'-[([5-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]pentyl]oxy)methyl]biphenyl-4-carbonitrile
-
4-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)butan-1-ol
-
-
4-benzyl-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
-
4-chloro-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
-
4-eicosan-sphingenine
-
-
4-hexadecyl-sphingenine
-
-
4-methyl-N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)cyclohexanecarboxamide
-
-
4-methyl-N-(4-methyl-2-piperidin-1-ylquinolin-6-yl)cyclohexanecarboxamide
-
-
4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)quinolin-6-yl]cyclohexanecarboxamide
-
-
4-methyl-N-[4-methyl-2-(4-pyrimidin-4-ylpiperazin-1-yl)-1,2-dihydroquinolin-6-yl]cyclohexanecarboxamide
-
-
4-O-(beta-D-glucopyranosyl)-N-butyl-2-O-butyl-1,5-dideoxy-1,5-imino-D-glucitol
-
-
4-octadecyl-sphingenine
-
-
4-octadecyl-threo-sphingenine
-
-
4-sphingenine
-
-
4-tetradecyl-sphingenine
-
-
4-undecyl-sphingenine
-
-
4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
-
-
4-[4-(naphthalen-2-ylsulfonyl)piperazin-1-yl]-2-(thiophen-2-yl)quinazoline
-
-
4-[[(4-chlorophenyl)sulfonyl]amino]-N-(2,5-dihydro-1,3-thiazol-2-yl)benzamide
-
-
5-((4-methylphenyl)thio)-quinazoline 2,4-diamine
-
inhibition of wild-type enzyme and chaperone function on mutant enzyme. Treated fibroblasts from patients with Gaucher disease show decreased levels of enzyme in their endoplasmic reticulum and increased levels in lysosomes. Compound stabilizes a domain III active-site loop
5-(3,5-dichlorophenoxy)-N-(4-pyridinyl)-2-furamide
-
inhibition of wild-type enzyme and chaperone function on mutant enzyme. Treated fibroblasts from patients with Gaucher disease show decreased levels of enzyme in their endoplasmic reticulum and increased levels in lysosomes. Compound stabilizes a domain III active-site loop
5-(N-ethyl-N-isopropyl)amiloride
-
5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin
-
potent inhibitor
5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin
-
potent inhibitor
6-amino-6-deoxy-5-N,6-N-[N'-(n-octyl)iminomethylidene]nojirimycin
-
-
6-bromo-6-deoxy-conduritol
6-bromo-conduritol-beta-epoxide
6-Hydroxydopamine
-
-
alkyl amines
-
-
Alkyl beta-glucosides
-
-
alpha-1-C-butyl-1-deoxynojirimycin
-
-
alpha-1-C-hexyl-1-deoxyimino-D-xylitol
-
-
alpha-1-C-hexyl-1-deoxynojirimycin
-
-
alpha-1-C-nonyl-1-deoxyimino-D-xylitol
-
strong inhibitor
alpha-1-C-propyl-1-deoxyimino-D-xylitol
-
-
alpha-1-C-propyl-1-deoxynojirimycin
-
-
beta-1-C-butyl-1,5-dideoxy-1,5-imino-L-iditol
-
-
beta-1-C-hexyl-1,5-dideoxy-1,5-imino-L-iditol
-
-
beta-1-C-propyl-1,5-dideoxy-1,5-imino-L-iditol
-
-
Ca2+
-
strong inhibition at 5 mM
calystegine A3
-
potent inhibitor
calystegine A5
-
-
calystegine B1
calystegine B2
calystegine B3
-
-
calystegine B4
-
-
calystegine C1
castanospermine
-
-
chondroitin sulfate
-
-
Co2+
-
complete inhibition at 5 mM
conduritol B epoxide
conduritol B-epoxide
-
-
conduritol beta-epoxide
irreversible inhibitor
conduritol-B-epoxide
irreversible
Cu2+
-
complete inhibition at 5 mM
cyclophellitol
-
oral application induces Gaucher like disease
cyclophellitol beta-epoxide ABP4
-
-
cyclophellitol beta-epoxide ABP5
-
-
cyclosporin A
-
deoxynojirimycin
Dextran sulfate
-
-
-
esomeprazole
-
glucal
-
-
gluconolactone
glucose
-
at 220 mM
glucosylsphingosine
glycosylamine
-
-
Hg2+
-
complete inhibition at 5 mM
iminoglycolipid
-
-
-
isofagomine
methyl ([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)acetate
-
-
Mg2+
-
strong inhibition at 5 mM
miglustat
Mn2+
-
strong inhibition at 5 mM
monoclonal antibodies
-
100% inhibition with F1 and F2, 60% inhibition with no. 61
-
N-(1-phenoxypropan-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(2,3-dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(2,3-dihydro-1H-inden-2-yl)-2-(thiophen-3-yl)quinazolin-4-amine
-
N-(2,3-dihydro-1H-inden-2-yl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine
-
N-(2,5-dihydro-1,3-thiazol-2-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
-
-
N-(2-(benzyloxy)ethyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(2-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(2-phenylethyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(3-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(3-phenylpropyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)-4-propylcyclohexanecarboxamide
-
-
N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)cyclopropanecarboxamide
-
-
N-(4-methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide
-
-
N-(4-phenylbutyl)-2-(pyridin-3-yl)quinazolin-4-amine
-
N-(5-adamantane-1-yl-methoxy)pentyl-deoxynojirimycin
-
extremely potent inhibitor for GBA2
N-(5-adamantane-1-yl-methoxypentyl)-deoxynojirimycin
-
N-(5-adamantane-1-yl-methoxypentyl)deoxynojirimycin
most powerful inhibitor of isoform GBA2
N-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-(5-chloro-2-methoxyphenyl)-N'-(2-methoxyethyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-(5-chloro-2-methoxyphenyl)-N'-(furan-2-ylmethyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-(phenylsulfonamido)benzamide
-
-
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-[(phenylsulfonyl)amino]benzamide
-
-
N-(5-ethyl-1,3,4-thiadiazolidin-2-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
-
-
N-(5-methylisoxazol-3-yl)-4-(phenylsulfonamido)benzamide
-
-
N-(5-methylisoxazol-3-yl)-4-[methyl(phenylsulfonyl)amino]benzamide
-
-
N-benzyl-4-[(phenylsulfonyl)amino]benzamide
-
-
N-benzyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-butyl deoxynojirimycin
miglustat or Zavesca
N-butyl-1-deoxynojirimycin
N-butyl-4-[(phenylsulfonyl)amino]benzamide
-
-
N-butyl-deoxynojirimycin
N-butyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-butyldeoxynojirimycin
N-butylisofagomine
-
-
N-carboxynonyldeoxynojirimycin
-
-
N-cycloheptyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-cycloheptyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-cyclohexyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-cyclooctyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-cyclooctyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-cyclopentyl-2-(pyridin-3-yl)quinazolin-4-amine
-
N-decyl-1-deoxynojirimycin
N-decylglycosylamine
-
-
N-dodecyl-1-deoxynojirimycin
N-dodecyldeoxynojirimycin
-
-
N-dodecylglycosylamine
-
-
N-hexadecylglycosylamine
-
-
N-hexyl-1-deoxynojirimycin
-
-
N-hexyl-D-glucosylsphingosine
N-hexylglycosylamine
-
-
N-hydroxy-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
-
N-methyl-1-deoxynojirimycin
N-methylcalystegine B2
-
-
N-nonyl-1-deoxynojirimycin
-
-
N-nonyl-deoxynojirimycin
-
-
N-nonyldeoxynojirimycin
N-octadecylglycosylamine
-
-
N-octylglycosylamine
-
-
N-phenyl-4-[(phenylsulfonyl)amino]benzamide
-
-
N-propyl-1-deoxynojirimycin
-
-
N-tetradecyl-1-deoxynojirimycin
-
-
N-tetradecylglycosylamine
-
-
N-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]-6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamide
-
N-[(3R)-tricyclo[3.3.1.13,7]dec-1-yl]-6-[(2S,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanamide
-
N-[2-(3,6-dihydropyridin-1(2H)-yl)-4-methylquinolin-6-yl]cyclohexanecarboxamide
-
-
N-[2-(diethylamino)-4-methyl-1,2-dihydroquinolin-6-yl]-4-methylcyclohexanecarboxamide
-
-
N-[2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenyl]acetamide
-
-
N-[2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethyl]acetamide
-
-
N-[2-[(3-chlorophenyl)amino]-4-methyl-1,2-dihydroquinolin-6-yl]-4-methylcyclohexanecarboxamide
-
-
N-[5-(adamantan-1-yl-methoxy)pentyl]-L-ido-1-deoxynojirimycin
-
N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
-
-
Ni2+
-
complete inhibition at 5 mM
nojirimycin bisulfite
-
-
p-hydroxymercuribenzoate
-
weak
p-nitrophenyl beta-D-glucopyranoside
-
inhibits mutant D223G
saposin C
-
-
-
SO42-
-
-
triazole-linked 6-BODIPY-2-deoxy-2-fluoro-beta-D-glucopyranosyl-N-phenyltrifluoroacetimidate inhibitor
semi-irreversible inhibitor
-
Triton X-100
-
additional information
-