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3.2.1.35: hyaluronoglucosaminidase

This is an abbreviated version!
For detailed information about hyaluronoglucosaminidase, go to the full flat file.

Word Map on EC 3.2.1.35

Reaction

hyaluronic acid hexasaccharide
+
H2O
=
hyaluronic acid disaccharide
 +
hyaluronic acid tetrasaccharide

Synonyms

BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.35 hyaluronoglucosaminidase

Activating Compound

Activating Compound on EC 3.2.1.35 - hyaluronoglucosaminidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
-
bovine serum albumine
-
-
-
Ca2+
-
enhances the activity of the enzyme
compound 48/80
-
-
Cu2+
-
enhances the activity of the enzyme
cysteine
-
60% activation
EDTA
-
up to 24% enhanced activity
Fe2+
-
enhances the activity of the enzyme
Hg2+
-
enhances the activity of the enzyme
interleukin 1-beta
acts synergistically with TNF-alpha to increase gene expression and activity
-
lysozyme
-
lysozyme can enhance HAase activity over a wide pH range from 3 to 9. Lysozyme can compete with HAase to form complexes with yaluronan, HAase is catalytically active over this whole pH domain when LYS limits its complexation with HA, and either the pI of bovine testicular HAase is high or positive patches on the surface of HAase allow the formation of electrostatic HA-HAase complexes at high pH values
-
N-(4,6-dimethylpyridin-2-yl)-(1-ethylindole-3-yl)acetamide
-
acts as an inhibitor at pH 7 and at pH 3.5 activity is increased to 134%
N-(4,6-dimethylpyridin-2-yl)-[5-bromo-1-(4-methyl)indole-3-yl]carboxamide
-
acts as an inhibitor at pH 7 and at pH 3.5 activity is increased to 117%
N-(pyridin-4yl)-[5-bromo-1-(4-fluorobenzyl)indole-3-yl]carboxamide
-
acts as an inhibitor at pH 7 and at pH 3.5 activity is increased to 120%
Pb2+
-
enhances the activity of the enzyme
TNF-alpha
acts synergistically with interleukin 1-beta to increase gene expression and activity
-
Zn2+
-
enhances the activity of the enzyme
additional information
-