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3.2.1.35: hyaluronoglucosaminidase

This is an abbreviated version!
For detailed information about hyaluronoglucosaminidase, go to the full flat file.

Word Map on EC 3.2.1.35

Reaction

hyaluronic acid hexasaccharide
+
H2O
=
hyaluronic acid disaccharide
 +
hyaluronic acid tetrasaccharide

Synonyms

BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.35 hyaluronoglucosaminidase

IC50 Value

IC50 Value on EC 3.2.1.35 - hyaluronoglucosaminidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.082
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.112
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.251
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.092
(2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.12
(2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.153
(2R,3S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.138
(2R,3S)-3-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.0285
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-21-cyclohexyl-28-hydroxy-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0264
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-23,28-dihydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0193
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-28-hydroxy-21-[(2Z)-2-methylbut-2-enoyl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0364
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-28-hydroxy-21-[(2Z)-2-methylbut-2-enoyl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0556
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-28-hydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.052
(3beta,16alpha,21beta,22alpha)-16,22-bis(acetyloxy)-28-hydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0302
(3beta,16alpha,21beta,22alpha)-16,23,28-trihydroxy-21-[(2Z)-2-methylbut-2-enoyl]-22-[[(2Z)-2-methylbut-2-enoyl]oxy]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0242
(3beta,16alpha,21beta,22alpha)-16,23,28-trihydroxy-22-[(2-methylbutanoyl)oxy]-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic aci
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.02
(3beta,16alpha,21beta,22alpha)-16,23,28-trihydroxy-22-[[(2Z)-2-methylbut-2-enoyl]oxy]-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosidur
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0552
(3beta,16alpha,21beta,22alpha)-16,28-bis(acetyloxy)-22-hydroxy-21-[(2Z)-2-methylbut-2-enoyl]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0515
(3beta,16alpha,21beta,22alpha)-16,28-bis(acetyloxy)-22-hydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0449
(3beta,16alpha,21beta,22alpha)-16,28-dihydroxy-21-[(2Z)-2-methylbut-2-enoyl]-22-[[(2Z)-2-methylbut-2-enoyl]oxy]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic a
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0405
(3beta,16alpha,21beta,22alpha)-16,28-dihydroxy-22-[[(2E)-2-methylbut-2-enoyl]oxy]-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosi
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0368
(3beta,16alpha,21beta,22alpha)-16,28-dihydroxy-22-[[(2Z)-2-methylbut-2-enoyl]oxy]-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosi
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0297
(3beta,16alpha,21beta,22alpha)-22-(acetyloxy)-16,28-dihydroxy-21-[(2Z)-2-methylbut-2-enoyl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0387
(3beta,16alpha,21beta,22alpha)-22-(acetyloxy)-16,28-dihydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0549
(3beta,16alpha,21beta,22alpha)-28-(acetyloxy)-16,22-dihydroxy-21-[(3Z)-3-methyl-2-oxopent-3-en-1-yl]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0487
(3beta,16alpha,21beta,22alpha)-28-(acetyloxy)-21-cyclohexyl-16,22-dihydroxy-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0241
(3beta,16alpha,22alpha)-16,28-dihydroxy-22-[[(2Z)-2-methylbut-2-enoyl]oxy]-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0249
(3beta,16alpha,22alpha)-16,28-dihydroxy-22-[[(2Z)-2-methylbut-2-enoyl]oxy]olean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0266
(3beta,16alpha,22alpha)-22-(cyclohexyloxy)-16,23,28-trihydroxyolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.0288
(3beta,16alpha,22alpha)-22-(cyclohexyloxy)-16,28-dihydroxy-23-oxoolean-12-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->2)-alpha-L-arabinopyranosyl-(1->3)]-beta-D-glucopyranosiduronic acid
Bos taurus
-
in 0.1 M acetate buffer (pH 4.0), at 37°C
0.21
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl ([1-[2-(benzyloxy)ethenylidene]but-2-yn-1-yl]oxy)ethaneperoxoate
Bos taurus
-
at pH 5.0
0.105
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl 11-phenoxyundecaneperoxoate
Bos taurus
-
at pH 5.0
0.037
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl 11-[[1-(2-phenylethenylidene)but-2-yn-1-yl]oxy]undecaneperoxoate
Bos taurus
-
at pH 5.0
2.006
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl 3-(2-phenylethenylidene)hex-4-yneperoxoate
Bos taurus
-
at pH 5.0
1.38
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl decaneperoxoate
Bos taurus
-
at pH 5.0
0.208
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl dodecaneperoxoate
Bos taurus
-
at pH 5.0
0.057
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl hexadecaneperoxoate
Bos taurus
-
at pH 5.0
0.039
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl octadecaneperoxoate
Bos taurus
-
at pH 5.0
0.071
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl tetradecaneperoxoate
Bos taurus
-
at pH 5.0
0.096
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl tridecaneperoxoate
Bos taurus
-
at pH 5.0
0.58
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl undecaneperoxoate
Bos taurus
-
at pH 5.0
0.188
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl [[1-(2-phenylethenylidene)but-2-yn-1-yl]oxy]ethaneperoxoate
Bos taurus
-
at pH 5.0
0.543
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl [[2-(2-phenylethenylidene)pent-3-yn-1-yl]oxy]ethaneperoxoate
Bos taurus
-
at pH 5.0
0.18 - 0.29
aristolochic acid
0.008 - 0.018
ascorbic acid palmitate
0.525
cimicifugic acid H
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.143
cimicifugic acid I
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.193
cimicifugic acid J
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.0801
clinopodic acid C
Bos taurus
-
in 0.1 M acetate buffer, at 37°C
0.0828
clinopodic acid E
Bos taurus
-
in 0.1 M acetate buffer, at 37°C
0.057
curcumin
Naja naja
-
IC50 is 0.057 mM
0.58
decyl gallate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.45
disodium cromoglycate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.144
fukinolic acid
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.026
glycyrrhizic acid
Homo sapiens
-
at pH 3.5
0.112
heptyl gallate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.253
hexyl gallate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.086
indomethacin
Naja naja
-
IC50 is 0.086 mM
0.378
L-ascorbic acid decanoate
Homo sapiens
-
at pH 3.5
0.076
L-ascorbic acid dodecanoate
Homo sapiens
-
at pH 3.5
0.05
L-ascorbic acid tridecanoate
Homo sapiens
-
at pH 3.5
0.143
L-ascorbic acid undecanoate
Homo sapiens
-
at pH 3.5
0.22
lansiumamide B
Deinagkistrodon acutus
-
pH and temperature not specified in the publication
3.3
lepidepyrone
Bos taurus
-
at 37°C
0.134
lycopic acid A
Bos taurus
-
in 0.1 M acetate buffer, at 37°C
0.141
lycopic acid B
Bos taurus
-
in 0.1 M acetate buffer, at 37°C
0.56
myricetin 3-O-beta-D-glucopyranoside
Naja atra
-
pH and temperature not specified in the publication
0.078
N-(4,6-dimethylpyridin-2-yl)-[5-bromo-1-(4-methyl)indole-3-yl]carboxamide
Bos taurus
-
pH: 7.0
0.046
N-(pyridin-4yl)-[5-bromo-1-(4-fluorobenzyl)indole-3-yl]carboxamide
Bos taurus
-
pH: 7.0
4
N-acetyl-L-cysteine
Bos taurus
-
in 0.2 M sodium acetate buffer pH 5.5 containing 0.15 M NaCl at 37°C
0.167
nonyl gallate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.902
octyl 3,4-dihydroxybenzoate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.113
octyl 3,5-dihydroxybenzoate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.106
octyl gallate
Bos taurus
-
in 0.1 M sodium acetate buffer, pH 4.0, at 37°C
0.005 - 0.008
partially sulfated planteose
0.04
partially sulfated verbascose
Apis mellifera
-
2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.040 mM and 0.003 mM
-
0.2401 - 0.545
rosmarinic acid
0.241
schizotenuin A
Bos taurus
-
in 0.1 M acetate buffer, at 37°C
0.573
shomaside A
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.43
shomaside B
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.663
shomaside C
Bos taurus
-
in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.658
shomaside D
Bos taurus
-
IC50 above 0.658 mM, in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.79
shomaside E
Bos taurus
-
IC50 above 0.79 mM, in 0.1 mM acetate buffer (pH 3.5), at 37°C
0.025
sulfated 2-hydroxyphenyl monolactobioside
Bos taurus
-
IC50 is 0.025 mM
0.006 - 0.015
sulfated hydroquinone galactoside
0.07
Tannic acid
Naja naja
-
IC50 is 0.070 mM