3.2.1.35: hyaluronoglucosaminidase

This is an abbreviated version!
For detailed information about hyaluronoglucosaminidase, go to the full flat file.

Reaction

Synonyms

BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.35 hyaluronoglucosaminidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
31	Activating Compound
8832	AA Sequence
24	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
1548	Disease/ Diagnostics
5	Expression
14	General Information
5	General Stability
91	IC50 Value
277	Inhibitors
29	KM Value [mM]
62	Localization
42	Metals/Ions
60	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
219	Organism
2	Pathway
39	PDB ID
76	pH Optimum
17	pH Range
10	pH Stability
3	pI Value
16	Posttranslational Modification
30	Protein Variants
44	Purification (Commentary)
17	Reaction
4	Reaction Type
181	Reference
1	Renatured (Commentary)
254	Source Tissue
52	Specific Activity [micromol/min/mg]
6	Storage Stability
274	Substrates and Products (Substrate)
41	Subunits
301	Synonyms
1	Systematic Name
67	Temperature Optimum [°C]
9	Temperature Range [°C]
10	Temperature Stability [°C]
1	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 3.2.1.35 - hyaluronoglucosaminidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

Mus musculus

-

cancer cell lines often secrete hyaluronidase, the enzyme might therefore be a marker for growing tumours

650509

biotechnology

2 entries

diagnostics

Homo sapiens

O43820, Q12794

increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer

652294

medicine

17 entries

molecular biology

Homo sapiens

-

the influence of hyaluronidase digestion modulates CD44 expression in various cancer cell lines

701231

pharmacology

Naja naja

-

isozyme NNH1 is a target for first aid agents from plants in snakebit therapy

664152

biotechnology

Bos taurus

-

a fluorescent substrate (FRET-HA) to quantitatively assess hyaluronidase activity is developed

695542

biotechnology

Bos taurus

-

novel products in hyaluronan digested by commercially available bovine testicular hyaluronidase are found which originate from a novel enzyme contaminat in the BTH

698133

medicine

Bos taurus

-

increasing absorption of fluids in dermal clysis, increasing diffusion of injected substances

171410

medicine

Apis mellifera

Q08169

enzyme is the target for immunotherapy of allergen reaction

653937

medicine

Homo sapiens

Q12794, Q12891

as major hyaluronidases in human cells, HYAL1 and HYAL2 may control intercellular interactions and microenvironment of tumour cells providing excellent targets for cancer treatment

694822

medicine

Apis mellifera

Q08169

this recombinant hyaluronidase can be applied for biochemical or medical purposes

682687

medicine

synthetic construct

EU152302

this recombinant hyaluronidase can be applied for biochemical or medical purposes

682687

medicine

Homo sapiens

-

human cancers grown in SCID mice regress dramatically following administration of purified testicular hyaluronidase. Hyaluronidase treatment also prevents lymph node invasion in a murine model for T-cell lymphoma

701231

medicine

Homo sapiens

-

hyaluronidase correlates with tumor progression which is documented in tumors of the male genito-urinary tract, in prostate and urinary bladder cancers. Aggressiveness of other human cancers also correlates with hyaluronidase, including breast and laryngeal cancer

701231

medicine

Bos taurus

-

hyaluronidase promotes Leishmania establishment in murine skin

700874

medicine

Homo sapiens

-

hyaluronidases are added to anticancer regimens, particularly in Europe. Tumors previously resistant to chemotherapy become sensitive when hyaluronidase is added. The enzyme may decrease intratumoral pressure, permitting drugs to penetrate the malignancy. Studies are available suggesting that hyaluronidase has intrinsic anti-tumor activity

701231

medicine

Homo sapiens

Q12794

it is assessed whether hyaluronic acid and HYAL-1 can predict progression to muscle invasion and recurrence among patients with non-muscle-invasive bladder carcinoma. In a cohort of 178 bladder carcinoma specimens HA and HYAL-1 expression is evaluated by immunohistochemistry and graded for intensity and area of staining. Association of HA and HYAL-1 staining with bladder carcinoma recurrence and muscle invasion is evaluated by univariate and multivariate models. HYAL-1 is a potential prognostic marker for predicting progression to muscle invasion and recurrence

697781

medicine

Homo sapiens

-

the codelivery of hyaluronidase enzyme with oncolytic adenoviruses is analysed to determine whether it improves the spread of the virus throughout tumors, thereby leading to a greater overall antitumor efficacy in tumor models: In mice injected with the adenovirus Ad5/35GFP and hyaluronidase (50 U), a significant increase in the number of GFP-expressing cells is observed when compared with animals injected with virus only. When the oncolytic adenoviruses Ad5OV or Ad5/35 OV are codelivered with 50 U of hyaluronidase, a significant delay in tumor progression is observed, which translates into a significant increase in the mean survival time of tumor-bearing mice compared with either of the monotherapy-treated groups. Furthermore, the mice that receive the combination of Ad5/35 OV and hyaluronidase show the best antitumor efficacy

691856

medicine

Homo sapiens

Q12794

the effect of anticoagulants on plasma HAase activity is evaluated and compared with the serum HAase activity that is devoid of anticoagulants. The plasma HAase activity in the presence of the recommended concentration of EDTA is highly comparable to that of the serum HAase activity. In contrast, citrated or heparinized plasma record a significantly reduced level of activity than that of the serum HAase activity. EDTA-treated plasma samples are a better choice compared with heparin and citrated samples to assess the HAase activity

699185

medicine

Homo sapiens

Q12794

hyaluronidase 1 is a prognostic indicator for both local recurrence and progression of non-muscle-invasive bladder cancer after transurethral resection

703581

medicine

Ovis aries

-

intravitreous injection of ovine hyaluronidase to patients with persistent vitreous hemorrhage is efficacious and has a favorable safety profile

703371

medicine

Homo sapiens

-

isoforms of hyaluronidase are predictors of a prostate cancer of good prognosis

706880

medicine

Bos taurus

-

hyaluronidase improves pharmacokinetic profiles of HI-6 dichloride and HI-6 dimethansulfonate. Hyaluronidase is supposed to increase tissue permeability and diminishes discomfort caused by the intramuscular injection

730998

medicine

Bos taurus

-

bovine hyaluronidase is an adjuvant for infiltration anesthesia. By degrading hyaluronan in the extracellular matrix, hyaluronidase increases membrane permeability, thereby rendering tissues more permeable to injected fluids. As a consequence, hyaluronidase reduces viscosity of hyaluronan which improves tissue diffusion and the resorption rate of excess fluids. Co-administration of hyaluronidase is a potential option to enhance the effectiveness of local anesthesia, increasing the analgesic efficacy with respect to the anesthetized area per time (e.g., subcutaneous and intramuscular injections). Hyaluronidase is used in ophthalmic surgery in combination with local anesthetics for peritubular, retrotubular or sub-Tenon's anesthesia and is established in other surgical disciplines, including dermatosurgery. Injection of hyaluronidase-based fillers in aesthetic dermatology

750477, 753495