3.2.1.35: hyaluronoglucosaminidase This is an abbreviated version! For detailed information about hyaluronoglucosaminidase, go to the full flat file .
Reaction
hyaluronic acid hexasaccharide +
H2O =
hyaluronic acid disaccharide +
hyaluronic acid tetrasaccharide
Synonyms BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1
ECTree
Source Tissue
Source Tissue on EC 3.2.1.35 - hyaluronoglucosaminidase
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primary pilocytic
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HPH-20
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Hyal-like activity is present in the apical and basolateral secretions from HBE cells where Hyals 1, 2, and 3 are expressed
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increased expression and activity is observed in tracheal sections and in bronchoalveolar lavage (BAL) obtained from subjects with asthma when compared with normal lung donors and healthy volunteers
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cell line derived from newborn H-2kb tsA58 transgenic mice
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cells form tubular structures after stimulation by angiogenic factors, e.g. the enzyme and the basic fibroblast growth factor bFGF, treatment leads to cell survival and prevents from apoptosis, respectively
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HPH-20
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glioblastoma cell line
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HPH-20
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tissue and cells
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high expression
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G1 tumour tissue
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G2 and G3 tumour tissues, and invasive tumour cells
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contains only HYAL2 but not HYAL1
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the enzyme translocates to the surface upon activation to function in extracellular matrix degradation
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contains only HYAL2 but not HYAL1
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derived from carcinoma cell lines
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testicular enzyme
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testicular
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from testis
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HPH-20
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Hyal3 is expressed in epididymal tissue/fluid, from where it is acquired by caudal mouse sperm in vitro
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high expression
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high expression
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low expression
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isoform HYAL 4 has little expression in the renal papilla
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isoforms HYAL 1 is highly expressed in the renal papilla
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isoforms HYAL 2 is highly expressed in the renal papilla
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isoforms HYAL 3 is highly expressed in the renal papilla
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high expression
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low expression
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high expression
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high expression
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high expression
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contains only HYAL2 but not HYAL1
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contains only HYAL2 but not HYAL1
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HPH-20
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Eusimulium latipes
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soluble and acrosome-bound isoforms
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soluble and acrosome-bound isoforms
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soluble and acrosome-bound isoforms
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from mice grafted with human-tumour-derived, enzyme secreting H460M or SA87 cells, and mice grafted with enzyme non-secreting CB 193 cells
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Hyal3 is expressed in epididymal tissue/fluid, from where it is acquired by caudal mouse sperm in vitro
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high expression
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649319 , 649321 , 649735 , 650273 , 651188 , 652643 , 677943 , 678640 , 679226 , 681742 , 681743 brenda
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171400 , 171409 , 171410 , 649310 , 650500 , 664596 , 695542 , 698133 , 699233 , 699474 , 699963 , 700874 , 701690 , 702753 , 703188 , 703288 , 705245 , 705485 , 714053 , 714911 , 714954 , 716094 , 717012 , 729118 , 729585 , 729842 , 730951 , 730998 brenda
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commercial preparation
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HPH-20
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high expression in adult male testis
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high expression in adult male testis, low expression in young male testis
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low expression
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Palamneus gravimanus
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contains a high molecular weight isoform
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Vipera elegans
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precursor
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additional information
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tissue distribution
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additional information
tissue distribution
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additional information
tissue distribution
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additional information
both splice variants of gene mgea5 are ubiquitously expressed in various tissues
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both splice variants of gene mgea5 are ubiquitously expressed in various tissues
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additional information
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during virus maturation in the host cell, the enzyme is located at the cell surface by a GPI-anchor
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additional information
level and pattern of Hyal1 expression in different tissues
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additional information
level and pattern of Hyal1 expression in different tissues
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additional information
level and pattern of Hyal1 expression in different tissues
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additional information
level and pattern of Hyal2 expression in different tissues
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additional information
level and pattern of Hyal2 expression in different tissues
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additional information
level and pattern of Hyal2 expression in different tissues
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additional information
level and pattern of Hyal3 expression in different tissues
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additional information
level and pattern of Hyal3 expression in different tissues
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additional information
level and pattern of Hyal3 expression in different tissues
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