3.2.1.35: hyaluronoglucosaminidase

This is an abbreviated version!
For detailed information about hyaluronoglucosaminidase, go to the full flat file.

Reaction

Synonyms

BmHYA1, BPH-20, BTH, BVH, chondritinase I, chondroitin sulfate hydrolase, chondroitinase, chondroitinase I, Cumulase, Dietrich's hyaluronidase, EC 3.2.1.34, endo-alpha-N-acetyl-hexosaminidase, endo-beta-N-acetyl-D-hexosaminidases hydrolase, endo-beta-N-acetylhexosaminidase, HAase, HPH-20, HU, human PH-20, Hya, Hya-1, Hya1, Hyal, Hyal 1, HYAL 2, HYAL 3, HYAL 4, Hyal-1, Hyal-2, Hyal-3, Hyal-4, Hyal-Ba, HYAL1, HYAL1-v1, HYAL1-v3, Hyal2, HYAL3, HYAL3-v1, HYAL3-v2, HYAL4, HYAL5, hyaluronate 4-glycanohydrolase, hyaluronidase, hyaluronidase 1, hyaluronidase 2, hyaluronidase 3, hyaluronidase PH20, hyaluronidase-1, hyaluronidase-2, hyaluronidase-4, hyaluronidase-5, hyaluronoglucosaminidase, hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase 1-type hyaluronidase, hyaluronoglucosaminidase 2, hyaluronoglucosidase, HYase, HYL, hylB, jaagsiekte sheep retrovirus receptor, LUCA-1, LUCA-2, Luca-3, LUCA2, MGEA5, Mu toxin, Neopermease, NNH1, NNH2, OTH, PH-20, rHuPH20, SFHYA1, SPAM1, sperm hyaluronidase 1, Sperm surface protein PH-20, spreading factor, testicular HAse, testicular hyaluronidase, vitrase, XKH1

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.35 hyaluronoglucosaminidase

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Results	in table
31	Activating Compound
8832	AA Sequence
24	Application
1	CAS Registry Number
32	Cloned(Commentary)
4	Crystallization (Commentary)
1548	Disease/ Diagnostics
5	Expression
14	General Information
5	General Stability
91	IC50 Value
277	Inhibitors
29	KM Value [mM]
62	Localization
42	Metals/Ions
60	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
219	Organism
2	Pathway
39	PDB ID
76	pH Optimum
17	pH Range
10	pH Stability
3	pI Value
16	Posttranslational Modification
30	Protein Variants
44	Purification (Commentary)
17	Reaction
4	Reaction Type
181	Reference
1	Renatured (Commentary)
254	Source Tissue
52	Specific Activity [micromol/min/mg]
6	Storage Stability
274	Substrates and Products (Substrate)
41	Subunits
301	Synonyms
1	Systematic Name
67	Temperature Optimum [°C]
9	Temperature Range [°C]
10	Temperature Stability [°C]
1	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.2.1.35 - hyaluronoglucosaminidase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glycoprotein

12 entries

no modification

Xenopus laevis

Q8UVT7

-

651288

proteolytic modification

3 entries

glycoprotein

Bothrops atrox

A0A2H4Z8F4

-

749985

glycoprotein

Chersonesometrus fulvipes

-

-

171404

glycoprotein

Crotalus durissus terrificus

B3EWP2

-

729332

glycoprotein

Homo sapiens

-

-

680043

glycoprotein

Homo sapiens

Q12794

-

678292

glycoprotein

Homo sapiens

O43820, Q12794, Q12891, Q2M3T9

-

716829

glycoprotein

Homo sapiens

-

mannosylation at Trp130 negatively regulate enzyme secretion and attenuates enzymatic activity

729859

glycoprotein

Macaca sp.

-

N-glycosylation is absolutely necessary for activity, deglycosylation leads to complete loss of activity, enzyme binds to lectins Con A, LEL, STL, PHA-e, Jacalin, and PSA, mannose is the major sugar within and at the terminal sequence of the glycans

651601

glycoprotein

Mus musculus

Q8VEI3

-

680047

glycoprotein

Synanceia horrida

-

-

171402

glycoprotein

Synanceia horrida

Q801Z8

the enzyme contains three potential N-glycosylation sites

665038

glycoprotein

Synanceia verrucosa

E5RWZ0

sequence is predicted to have potential N-glycosylation sites at the positions 78, 169 and 364

716966

proteolytic modification

Homo sapiens

O60502

posttranslational modification of a larger protein of 130 kDa to a 75 kDa form

649571

proteolytic modification

Synanceia horrida

Q801Z8

the precursor enzyme contains a signal sequence for targeting into endoplasmic reticulum

665038

proteolytic modification

Synanceia verrucosa

E5RWZ0

sequence contains a N-terminal signal pepitde of 28 amino acids

716966